Spots Global Cancer Trial Database for Bone Marrow Transplantation in Treating Patients With Chronic Lymphocytic Leukemia

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Trial Identification

Brief Title: Bone Marrow Transplantation in Treating Patients With Chronic Lymphocytic Leukemia

Official Title: Bone Marrow Transplantation for Chronic Lymphocytic Leukemia

Study ID: NCT00002844

Conditions

Leukemia

Interventions

Cyclophosphamide

Allogeneic Bone Marrow Transplantation

Autologous Bone Marrow Transplantation

Total Body Irradiation (TBI)

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of bone marrow transplantation in treating patients with chronic lymphocytic leukemia.

Detailed Description: OBJECTIVES: Examine the potential role for high dose cyclophosphamide, total body irradiation and bone marrow transplantation for patients with chronic lymphocytic leukemia who are at high risk for disease progression. OUTLINE: Patients receive daily intravenous infusions of cyclophosphamide for two days, followed by total body irradiation in four daily exposures. After completion of the total body irradiation, allogeneic or autologous bone marrow is infused intravenously. PROJECTED ACCRUAL: 50 patients are expected to be accrued.