Spots Global Cancer Trial Database for S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia

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Trial Identification

Brief Title: S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia

Official Title: S0106B, Stem Cell Origin in AML: Prognostic and Therapeutic Implications

Study ID: NCT01575535

Conditions

Leukemia

Interventions

gene expression analysis

flow cytometry

fluorescence activated cell sorting

laboratory biomarker analysis

medical chart review

Study Description

Brief Summary: RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research trial studies bone marrow samples from women with acute myeloid leukemia.

Detailed Description: OBJECTIVES: * Estimate the proportion of acute myeloid leukemia (AMLs) that originate in CD33+ precursors or in which uncontrolled growth is limited to CD33+ precursors. * Explore whether there is an association between the cellular origin of AML (i.e., origination in CD33+ precursors or not) and cytogenetic, molecular, and other patient characteristics. * Explore whether overall survival (OS), event-free survival (EFS), disease-free survival (DFS), response rate (RR), or relapse rate is improved for patients with AMLs that originate in CD33+ precursors or in which uncontrolled growth is limited to CD33+ precursors compared to patients with clonally involved cells not detected. OUTLINE: Archived bone marrow samples are analyzed for CD33+ progenitors, X-chromosome inactivation, and somatic mutations (t(8;21), inv(16), FLT3/ITD, NPM1, CEBPA, KIT) by fluorescence-activated cell sorting, long-term culture in hypoxic condition in cytokine-containing liquid media, and flow cytometry. Results are then compared with each patient clinical data.