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Brief Title: Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients
Official Title: A Study of Rasburicase Treatment for Chemotherapy of Malignancy-Induced Hyperuricemia in Patients With a History of Asthma Allergies
Study ID: NCT00186940
Brief Summary: This is a multi-center trial for rasburicase in children at high risk of tumor lysis syndrome who have a history of asthma/atopy. The main purpose of this study is to establish the safety of this drug in patients with a history of asthma or severe allergies.
Detailed Description: Because they were excluded from most of the clinical trials of non-recombinant urate oxidase and rasburicase, the safety of rasburicase in this population is not known, though preliminary data indicates that the drug is safe. The primary objective of this study is to estimate the proportion of grade 3 or 4 allergic reactions to rasburicase in patients with a history of asthma or severe allergy (to antigens other than rasburicase or other urate oxidases) treated with rasburicase for the prevention or treatment of malignancy or chemotherapy-induced hyperuricemia. Patients at risk of tumor lysis syndrome with a history of asthma/atopy will be treated with rasburicase according to standard practice and observed for allergic reactions.
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Stanford University, Palo Alto, California, United States
Rady Children's Hospital, San Diego, California, United States
Peyton Manning Children's Hospital at St. Vincent, Indianapolis, Indiana, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Children's Hospital Michigan, Detroit, Michigan, United States
Columbia University Medical Center, New York, New York, United States
Rhode Island Hospital, Providence, Rhode Island, United States
St.Jude Children's Research Hospital, Memphis, Tennessee, United States
Cook Children's Medical Center, Fort Worth, Texas, United States
MD Anderson Cancer Center, Houston, Texas, United States
Mid-West Children's Cancer Center, Milwaukee, Wisconsin, United States
Name: Raul C. Ribeiro, MD
Affiliation: St. Jude Children's Research Hospital
Role: PRINCIPAL_INVESTIGATOR