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Spots Global Cancer Trial Database for Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients

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Trial Identification

Brief Title: Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients

Official Title: A Study of Rasburicase Treatment for Chemotherapy of Malignancy-Induced Hyperuricemia in Patients With a History of Asthma Allergies

Study ID: NCT00186940

Interventions

Rasburicase

Study Description

Brief Summary: This is a multi-center trial for rasburicase in children at high risk of tumor lysis syndrome who have a history of asthma/atopy. The main purpose of this study is to establish the safety of this drug in patients with a history of asthma or severe allergies.

Detailed Description: Because they were excluded from most of the clinical trials of non-recombinant urate oxidase and rasburicase, the safety of rasburicase in this population is not known, though preliminary data indicates that the drug is safe. The primary objective of this study is to estimate the proportion of grade 3 or 4 allergic reactions to rasburicase in patients with a history of asthma or severe allergy (to antigens other than rasburicase or other urate oxidases) treated with rasburicase for the prevention or treatment of malignancy or chemotherapy-induced hyperuricemia. Patients at risk of tumor lysis syndrome with a history of asthma/atopy will be treated with rasburicase according to standard practice and observed for allergic reactions.

Keywords

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Stanford University, Palo Alto, California, United States

Rady Children's Hospital, San Diego, California, United States

Peyton Manning Children's Hospital at St. Vincent, Indianapolis, Indiana, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Children's Hospital Michigan, Detroit, Michigan, United States

Columbia University Medical Center, New York, New York, United States

Rhode Island Hospital, Providence, Rhode Island, United States

St.Jude Children's Research Hospital, Memphis, Tennessee, United States

Cook Children's Medical Center, Fort Worth, Texas, United States

MD Anderson Cancer Center, Houston, Texas, United States

Mid-West Children's Cancer Center, Milwaukee, Wisconsin, United States

Contact Details

Name: Raul C. Ribeiro, MD

Affiliation: St. Jude Children's Research Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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