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Brief Title: A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies
Official Title: An Open, Multi-center, Randomized Trial Comparing Haploidentical HSCTs From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies
Study ID: NCT04547049
Brief Summary: An open, multi-center, randomized trial comparing haploidentical HSCTs from young non-first-degree and older first-degree donors in hematological malignancies
Detailed Description: This is an open, multi-center, randomized trial comparing the clinical outcomes of haploidentical HSCTs from young non-first-degree and older first-degree donors in hematological malignancies. This study is indicated for patients with hematological malignancies including ALL, AML, MDS and NHL who are eligible to haploidentical HSCTs. 2 groups of patients will be enrolled with 80 in each group. The clinical criteria including survival, relapse, transplantation-related mortality will be monitored.
Minimum Age: 14 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, , China
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, , China
The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, , China
Zhejiang Provincial People's Hospital, Hangzhou, , China
Jinhua Hospital of Zhejiang University, Jinhua, , China
Ningbo Hospital of Zhejiang University, Ningbo, , China
The Affiliated People's Hospital of Ningbo University, Ningbo, , China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, , China
Name: Yi Luo, MD
Affiliation: First Affiliated Hospital of Zhejiang University
Role: PRINCIPAL_INVESTIGATOR