Spots Global Cancer Trial Database for Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Cord Blood Transplant for Hematologic Malignancy
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Trial Identification
Brief Title: Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Cord Blood Transplant for Hematologic Malignancy
Official Title: A Phase I Trial to Determine Safety and Tolerability of Ex Vivo Expanded Human Myeloid Progenitor Cells (CLT-008) Infused 24 Hours Post-Transplant to Support Allogeneic Umbilical Cord Blood Transplantation for Hematologic Malignancies
Study ID: NCT00891137
Interventions
Study Description
Brief Summary: Ex vivo expanded human myeloid progenitor cells (hMPCs; CLT-008) have the potential to accelerate neutrophil recovery in patients receiving myeloablative conditioning as part of an umbilical cord blood transplant for hematologic cancer. In this study, the safety and tolerability of CLT-008 administered 24 hours after an umbilical cord blood transplant will be determined by monitoring for adverse reactions, neutrophil and platelet recovery, hematopoietic chimerism, graft-versus-host disease (GVHD), and infections.
Detailed Description:
Keywords
Eligibility
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Children's Hospital of Orange County, Orange, California, United States
Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States
Children's National Medical Center, Washington, District of Columbia, United States
Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, Illinois, United States
University of Minnesota: Masonic Cancer Center, BMT Clinic, and Fairview Medical Center, Minneapolis, Minnesota, United States
Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio, United States
Nationwide Children's Hospital, Columbus, Ohio, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Contact Details
Name: John E Wagner, MD
Affiliation: University of Minnesota
Role: PRINCIPAL_INVESTIGATOR
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