Spots Global Cancer Trial Database for Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia

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Trial Identification

Brief Title: Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia

Official Title: Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL

Study ID: NCT01626183

Conditions

Leukemia

Interventions

RNA analysis

proteomic profiling

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).

Detailed Description: OBJECTIVES: * Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus). * Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow). OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.