Spots Global Cancer Trial Database for Primary Liver Cancer Early Detection
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Trial Identification
Brief Title: Primary Liver Cancer Early Detection
Official Title: Early Detection of Primary Liver Cancer Based on cfDNA Methylation: A Multi-Center Case-Control Study (PRIMe-liver)
Study ID: NCT05996666
Conditions
Interventions
Study Description
Brief Summary: In the recently published multi-center, prospective, single-blind study (THUNDER study), using the methylation signal in cfDNA isolated from the peripheral blood to detect the six types of cancer, the sensitivity for liver cancer detection achieved 87.8%, with a specificity of 98.9%. In this study, a multicenter, case-control study is designed to establish an early cancer detection model based on cfDNA methylation biomarkers using qPCR to detect primary liver cancer and further validate the performance of the model.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Jilin university first hospital, Changchun, Jilin, China
Eastern Hepatobiliary Surgery Hospital, Shanghai, Shanghai, China
Contact Details
Name: Tian Yang
Affiliation: Eastern Hepatobiliary Surgery Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Nanya Wang
Affiliation: The First Hospital of Jilin University
Role: PRINCIPAL_INVESTIGATOR
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