Spots Global Cancer Trial Database for bTAE-HAIC Combined With System Therapy for Intermediate-advanced Huge HCC
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Trial Identification
Brief Title: bTAE-HAIC Combined With System Therapy for Intermediate-advanced Huge HCC
Official Title: Sequential bTAE-HAIC Combined With Lenvatinib and Camrelizumab for Intermediate-advanced Huge Hepatocellular Carcinoma
Study ID: NCT06061276
Study Description
Brief Summary: This study intends to evaluate the efficacy and safety of blank- microsphere transcatheter arterial embolization-hepatic arterial infusion chemotherapy of oxaliplatin, 5-fluorouracil and leucovorin (bTAE-HAIC) plus Lenvatinib and Camrelizumab for patients with intermediate-advanced huge hepatocellular carcinoma.
Detailed Description: Blank-microsphere transcatheter arterial embolization (bTAE) and hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, 5-fluorouracil and leucovorin are effective and safe for hepatocellular carcinoma. Lenvatinib is non-inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma. Camrelizumab, a programmed cell death protein-1 (PD-1) inhibitor, is effective and tolerable in patients with unresectable hepatocellular carcinoma. No study has evaluated bTAE-HAIC plus Lenvatinib and Camrelizumab. Thus, the investigators carried out this prospective, single-arm study to find out it.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Sun Yat-sen University Cancer Center, Guanzhou, Guangdong, China
Contact Details
Name: Zhimei Hunag, MD
Affiliation: Sun Yat-sen University
Role: STUDY_DIRECTOR
Name: Jinhua Huang, Profession
Affiliation: Sun Yat-sen University
Role: STUDY_DIRECTOR
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