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Spots Global Cancer Trial Database for Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy

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Trial Identification

Brief Title: Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy

Official Title: Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy

Study ID: NCT05169177

Conditions

Liver Neoplasm

Interventions

Study Description

Brief Summary: This observational study will investigate the properties of image files standardly collected during radiation therapy treatment in a cross-section of liver cancer patients who received stereotactic ablative body radiation therapy (SABR) after trans-catheter arterial chemo emobilisation (TACE). Specifically, it will determine whether the radio-opaque contrast agents in the image files can be detected by tumour-tracking software (KIM).

Detailed Description: * Sites will collect image files from the Cancer Radiation Therapy Systems and the medical records of eligible participants. For patient who do not have implanted markers, research personnel (a radiation oncologist, medical physicist or radiation therapist) will manually outline the visible contrast mass. This outline is considered the 'ground truth' of the location of the contrast mass. To ensure its accuracy, the ground truth contrast mass location will be checked by research personnel from another study site. * Image and ground truth data collected from 80% of participants will be used by University of Sydney researchers to develop the KIM algorithm to detect and track the radio-opaque contrast agents with sufficient robustness to provide justification for the prospective use of KIM as a real-time image guided radiation therapy tool for liver cancer patients. * The developed KIM software will be applied by site Medical Physicist(s) to the treatment imaging data from the remaining 20% of participants the images. Tumour positions produced by KIM will be compared with a 'ground truth' manual delineation.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Calvary Mater Newcastle Hospital, Waratah, New South Wales, Australia

Westmead Hospital, Westmead, New South Wales, Australia

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

The Austin Hospital, Melbourne, Victoria, Australia

Contact Details

Name: Paul Keall, PhD

Affiliation: University of Sydney

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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