Spots Global Cancer Trial Database for Chemoembolization of Non-resectable Non-metastatic Hepatocellular Carcinoma Using Embolization Microspheres

Study Description

Brief Summary: Chemoembolization is a recognized treatment strategy for hepatocellular carcinoma (HCC) * classical chemoembolization consists in injecting an emulsion of an anticancer agent in Lipiodol® via the hepatic artery * doxorubicin, an anthracycline, is the most frequently used drug in lipiodol chemoembolization (LCE) * however, less than half of HCC respond favourably to classical lipiodol chemoembolization (LCE) with doxorubicin/Lipiodol® In this trial, we propose to introduce in clinical practice a strategy based on idarubicin to achieve a more effective antitumor effect for the following reasons, recently pointed out by our team: * idarubicin is an anthracycline that penetrates tumour cells more quickly and is more cytotoxic than doxorubicin on hepatocellular carcinoma cell lines * idarubicin is injected in a solution of embolization microspheres of a diameter of (300-500µm), which all the progressive and controlled release of the anticancer drug, whereas the doxorubicin/Lipiodol® emulsion is unstable

Detailed Description:

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Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

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