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Brief Title: Safety and Efficacy of SPH4336 in Combination With Endocrine Therapy in the Treatment of Locally Advanced or Metastatic Breast Cancer
Official Title: A Phase II/III Study of SPH4336 in Combination With Endocrine Therapy in the Treatment of HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer That Progressed on CDK4/6 Inhibitor Combined With Endocrine Therapy
Study ID: NCT05860465
Brief Summary: This study evaluated the safety and efficacy of SPH4336 in combination with endocrine therapy in the treatment of locally advanced or metastatic breast cancer that progressed on CDK4/6 inhibitor combined with endocrine therapy.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Affiliated Cancer Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Liuzhou people's Hospital, Liuzhou, Guangxi, China
The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Harbin Medical University cancer Hospital, Harbin, Heilongjiang, China
Anyang Cancer Hospital, Anyang, Henan, China
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
Xiangyang Cancer Hospital, Wuhan, Hubei, China
Jiangsu Cancer Hospital, Nanjing, Jiangsu, China
Jiangsu Province Hospital, Nanjing, Jiangsu, China
Jilin Cancer Hospital, Changchun, Jilin, China
The First Hospital of China Medical University, Shenyang, Liaoning, China
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shanxi, China
The second people's hospital of neijiang, Neijiang, Sichuan, China
Yunnan Cancer Hospital, Kunming, Yunnan, China
Zhejiang cancer Hospital, Hangzhou, Zhejiang, China
Peking Union Medical College Hospital, Beijing, , China
The First Affiliated Hospital of Bengbu Medical College, Bengbu, , China
Fujian Cancer Hospital, Fuzhou, , China
First Affiliated Hospital of Kunming Medical University, Kunming, , China
Shenzhen Hospital of University of Hong Kong, Shenzhen, , China