Spots Global Cancer Trial Database for A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer
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Trial Identification
Brief Title: A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer
Official Title: A Randomized, Double-blind, Phase III Trial to Compare the Efficacy and Safety of AK104 Combined With Chemotherapy to Tislelizumab Combined With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer (NSCLC)
Study ID: NCT05990127
Conditions
Study Description
Brief Summary: This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK104 combined chemotherapy versus Tislelizumab combined chemotherapy in first-line treatment of Locally advanced or metastatic NSCLC with PD-L1 TPS \< 1%.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The first affiliated hospital of bengbu medical college, Bengbu, Anhui, China
Anhui provincial hospital, Hefei, Anhui, China
Anhui provincial cancer hospital, Hefei, Anhui, China
The first affiliated hospital of wannan medical college, Wuhu, Anhui, China
Cancer hospital, Chinese academy of medical sciences and Peking union medical college, Beijing, Beijing, China
The Fifth Medical Center of the Chinese People's Liberation Army General Hospital, Beijing, Beijing, China
Beijing Cancer Hospital, Beijing, Beijing, China
Beijing Chest hospital, Beijing, Beijing, China
Chongqing University Cancer Hospital, Chongqing, Chongqing, China
Fujian cancer hospital, Fuzhou, Fujian, China
Zhangzhou municipal hospital of fujian province, Zhangzhou, Fujian, China
Gansu provincial cancer hospital, Lanzhou, Gansu, China
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Affiliated cancer hospital and institute of guangzhou medical university, Guangzhou, Guangdong, China
Nanfang hospital, Guangzhou, Guangdong, China
Cancer hospital Chinses academy of medical sciences， shenzhen center, Shenzhen, Guangdong, China
Hainan cancer hospital, Haikou, Hainan, China
Affiliated hospital of Hebei university, Baoding, Hebei, China
The second people's hospital of Hengshui, Hengshui, Hebei, China
The Second Hospital of HeBei Medical University, Shijiazhuang, Hebei, China
The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Tangshang people's hospital, Tangshan, Hebei, China
Harbin medical university cancer hospital, Harbin, Heilongjiang, China
Jiamusi Tuberculosis Prevention and Control Hospital (Jiamusi Cancer Hospital), Jiamusi, Heilongjiang, China
The first hospital of Qiqihar, Qiqihar, Heilongjiang, China
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
Nanyang central hospital, Nanyang, Henan, China
The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan, China
Henan Cancer Hospital, Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Renmin Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Cancer Hospital, Wuhan, Hubei, China
Xiangya Hospital of Central South University, Changsha, Hunan, China
The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Hunan Cancer Hospital, Changsha, Hunan, China
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
The affiliated hospital of xuzhou medical university, Xuzhou, Jiangsu, China
First Affiliated Hospital of Gannan medical college, Ganzhou, Jiangxi, China
First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
The first hospital of Jilin Universit, Changchun, Jilin, China
Tonghua Central Hospital, Tonghua, Jilin, China
The First Hospital of China medical University, Shenyang, Liaoning, China
Liaoning cancer hospital, Shenyang, Liaoning, China
General hospital of ningxia medical university, Yinchuan, Ningxia, China
Qinghai university affiliated hospital, Xining, Qinghai, China
Binzhou medical university hospital, Binzhou, Shandong, China
Shandong Cancer Hospital, Jinan, Shandong, China
The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
Weifang NO.2 people's Hospital, Weifang, Shandong, China
Zhongshan Hospital, Fudan university, Shanghai, Shanghai, China
Changzhi people's hospital, Changzhi, Shanxi, China
Shanxi Cancer hospital, Taiyuan, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Sichuan Cancer Hospital, Chengdu, Sichuan, China
Mianyang central hospital, Mianyang, Sichuan, China
The Second People's Hospital of Yibin City, Yibin, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
Tianjin Chest Hospital, Tianjin, Tianjin, China
Xinjiang Medical University Cancer Hospital, Urumqi, Xinjiang, China
Yunnan Cancer Hospital /the Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
The First Affiliated Hospital, Zhejiang University School of Medicine (FAHZU), Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Contact Details
Name: Jie Wang, M.D.
Affiliation: Cancer hospital, Chinese academy of medical sciences and Peking union medical college
Role: PRINCIPAL_INVESTIGATOR
Name: Qingming Wang
Affiliation: Henan Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
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