Spots Global Cancer Trial Database for Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
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Trial Identification
Brief Title: Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
Official Title: PrOspective Non-interventional Study in Patients With Locally Advanced or Metastatic TRK Fusion Cancer Treated With Larotrectinib
Study ID: NCT04142437
Interventions
Study Description
Brief Summary: In this observational study researcher want to learn more about the effectiveness of drug VITRAKVI (generic name: larotrectinib) and how well the drug is tolerated during routine use in patients with TRK fusion cancer which is locally advanced or spread from the place where it started to other places in the body. TRK fusion cancer is a term used to describe a variety of common and rare cancers that are caused by a change to the NTRK (Neurotrophic Tyrosine Kinase) gene called a fusion. During this fusion, an NTRK gene joins together, or fuses, with a different gene. This joining results in the activation of certain proteins (TRK fusion proteins), which can cause cancer cells to multiply and form a tumor. VITRAKVI is an approved drug that blocks the action of the NTRK gene fusion. This study will enroll adult and paediatric patients suffering from a solid tumor with NTRK gene fusion for whom the decision to treat their disease with VITRAKVI has been made by their treating physicians. During the study, patients' medical information such as treatment information with VITRAKVI, other medication or treatments, changes in disease status and other health signs and symptoms will be collected within the normal medical care by the treating doctor. Participants will be observed over a period from 24 to 60 months.
Detailed Description:
Keywords
Eligibility
Minimum Age: 1 Month
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Banner Desert Medical Center, Mesa, Arizona, United States
California Research Inst., Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
UCLA - Mattel Children's Hospital, Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
UCSF Benioff Children's Hospital Oakland, Oakland, California, United States
Stanford Univ Med Ctr. / Lucile Packard Children's Hosp, Palo Alto, California, United States
Providence Health System - Southern California, Santa Monica, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States
SCL Health, Grand Junction, Colorado, United States
Yale University, New Haven, Connecticut, United States
Mayo Clinic, Jacksonville, Florida, United States
University of Miami, Miami, Florida, United States
Nicklaus Children's Hospital, Miami, Florida, United States
Nemours Children's Hospital, Orlando, Florida, United States
Fort Wayne Medical Oncology Hematology, Fort Wayne, Indiana, United States
Regional Health Hope Center, Terre Haute, Indiana, United States
Cancer Center of Kansas, Wichita, Kansas, United States
Maine Health, South Portland, Maine, United States
Univ. of Maryland / Greenebaum Comp. Cancer Ctr., Baltimore, Maryland, United States
Johns Hopkins / Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
Frederick Health-James M Stockman Cancer Institute, Frederick, Maryland, United States
Tufts / Neely Cancer Center, Boston, Massachusetts, United States
Boston Children's / Dana Farber, Boston, Massachusetts, United States
Detroit Clinical Research Center, Farmington Hills, Michigan, United States
Sparrow Cancer Center, Lansing, Michigan, United States
Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
Atlantic Hem Onc / Morristown Medical Center, Morristown, New Jersey, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Great Lakes Cancer Center, Buffalo, New York, United States
Memorial Sloan Kettering Children's Cancer Center, New York, New York, United States
Staten Island Univ. Hospital (Northwell Health), Staten Island, New York, United States
Levine Cancer Center, Charlotte, North Carolina, United States
East Carolina University / Vidant Health, Greenville, North Carolina, United States
Ohio State Comp. Cancer Ctr. / James Cancer Hospital, Columbus, Ohio, United States
Mercy Health Youngstown, Youngstown, Ohio, United States
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
University of Pennsylvania (Penn Med), Philadelphia, Pennsylvania, United States
Allegheny Health Network, Pittsburgh, Pennsylvania, United States
Medical Univ. of South Carolina, Charleston, South Carolina, United States
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
UT Southwestern Medical Center / Children's Health, Dallas, Texas, United States
MD Anderson Cancer Center, Houston, Texas, United States
Intermountain Healthcare - Intermountain Medical Center, Murray, Utah, United States
Intermountain Healthcare - Dixie Regional Medical Center, Saint George, Utah, United States
Univ. of Utah / Huntsman Cancer Center, Salt Lake City, Utah, United States
Seattle Children's, Seattle, Washington, United States
West Virginia University, Morgantown, West Virginia, United States
Gundersen Health System, La Crosse, Wisconsin, United States
SSM Health Cancer Center - Dean Medical Group, Madison, Wisconsin, United States
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Contact Details
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