Spots Global Cancer Trial Database for A Study of DCC-2701 in Participants With Advanced Solid Tumors

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Trial Identification

Brief Title: A Study of DCC-2701 in Participants With Advanced Solid Tumors

Official Title: A Multicenter Phase 1 Ascending Dose Study of DCC-2701 To Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Patients With Advanced Solid Tumors

Study ID: NCT02228811

Conditions

Locally Advanced Tumors

Metastatic Solid Tumors

Cancers With MET Genomic Alterations

Cancers With TRK Genomic Alterations

Interventions

DCC-2701 tablet

Study Description

Brief Summary: The main purpose of this study is to investigate the safety of the investigational drug DCC-2701 and whether it will work to help people who have advanced solid tumors or cancer that has spread to other parts of the body.

Detailed Description: This is a first-in-human study of DCC-2701. The primary purpose of this study is to determine what dose of DCC-2701, can be given safely to patients with advanced solid tumors. The study will have two phases. The first phase will assess escalating doses of DCC-2701 in order to determine the maximally tolerated dose (MTD) and the optimal dosing regimen (ODR) of DCC-2701. Once the MTD and ODR is established, a dose expansion phase will further evaluate the safety of DCC-2701, as well as the activity of DCC-2701 in select solid tumor types.