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Spots Global Cancer Trial Database for Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation

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Trial Identification

Brief Title: Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation

Official Title: The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function

Study ID: NCT00009711

Study Description

Brief Summary: RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment. PURPOSE: This clinical trial studies lung function in pediatric patients who have undergone bone marrow transplant.

Detailed Description: OBJECTIVES: * Determine the delayed effects of bone marrow transplantation preparative regimens on pulmonary function in children surviving at least 5 years after transplantation for hematologic malignancy. * Determine the relationship between pulmonary function and growth rates in these patients. * Determine the effect of growth hormone treatment on pulmonary function in these patients. * Determine the relationship between pulmonary function and age at time of transplantation in these patients. * Determine the incidence and severity of restrictive pulmonary disease, and whether these factors vary with increasing time after transplantation in these patients. OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement. Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated. PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.

Eligibility

Minimum Age:

Eligible Ages: CHILD

Sex: ALL

Healthy Volunteers: No

Locations

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Contact Details

Name: Jean E. Sanders, MD

Affiliation: Fred Hutchinson Cancer Center

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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