Spots Global Cancer Trial Database for Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm

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Trial Identification

Brief Title: Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm

Official Title: Comparison of Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cm With Micropapillary and Solid Subtype Positive by Frozen Section: A Prospective, Observational, Multicenter Cohort Study

Study ID: NCT05838053

Conditions

Lung Adenocarcinoma

Interventions

Lobectomy with systemic lymph node dissection

Segmentectomy with systemic lymph node dissection

Study Description

Brief Summary: This study aims to evaluate the superiority in recurrence-free survival of lobectomy compared with segmentectomy in patients with lung adenocarcinoma ≤ 2 cm with micropapillary and solid subtype positive by intraoperative frozen sections.

Detailed Description: At present, the technology of intraoperative frozen section has gradually matured, which can diagnose the benign and malignant tumors and guide the resection strategy for peripheral small-sized lung adenocarcinoma. Travis et al. reported high specificity of intraoperative frozen section in the identification of micropapillary components, confirming that intraoperative frozen section may guide the selection of surgical procedures. However, there is still little evidence whether segmentectomy is appropriate for invasive adenocarcinoma without micropapillary patterns. This prospective and multi-center study was aimed to evaluate the superiority in recurrence free survival and overall survival of lobectomy compared with segmentectomy in patients with lung adenocarcinoma (≤ 2 cm) containing positive micropapillary components.