Spots Global Cancer Trial Database for Durvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic Squamous or Non-Squamous NSCLC
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Trial Identification
Brief Title: Durvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic Squamous or Non-Squamous NSCLC
Official Title: A Randomized Trial of Durvalumab and Tremelimumab ± Platinum-Based Chemotherapy in Patients With Metastatic (Stage IV) Squamous or Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Study ID: NCT03057106
Conditions
Study Description
Brief Summary: Durvalumab is a new type of drug for many kinds of cancer. It is considered "immunotherapy" and not "chemotherapy". Laboratory tests show that it works by allowing the immune system to detect cancer and reactivate the immune response. This may help to slow down the growth of cancer or may cause cancer cells to die. Durvalumab has been shown to shrink tumours in animals and has been studied in more than 5000 people and seems promising. Tremelimumab is a new type of drug for various types of cancers. It works in a similar way to durvalumab and may improve the effect of durvalumab. Tremelimumab may also help slow the growth of the cancer cells or may cause cancer cells to die. It has been shown to shrink tumours in animals and has been studied in over 1200 people and seems promising.
Detailed Description: Combinations of durvalumab and tremelimumab have also been studied. While the combination has been studied in over 200 people, it is not clear if it can offer better results when it is combined with chemotherapy. Recently, immunotherapies that target the PD-1/PD-L1 axis have shown promise in treating patients with non-small cell lung cancer.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Campbelltown Hospital, Campbelltown, New South Wales, Australia
Coffs Habour Health Campus - NCCI, Coffs Harbour, New South Wales, Australia
Concord Repatriation General Hospital, Concord, New South Wales, Australia
Nepean Hospital, Kingswood, New South Wales, Australia
St. George Hospital, Cancer Care Centre, Kogarah, New South Wales, Australia
The Tweed Hospital, Lismore, New South Wales, Australia
Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, New South Wales, Australia
Prince of Wales Hospital, Randwick, New South Wales, Australia
Princess Alexandra Hospital, Brisbane, Queensland, Australia
The Prince Charles Hospital, Chermside, Queensland, Australia
Mater Research Institute South Brisbane, South Brisbane, Queensland, Australia
Gold Coast University Hospital, Southport, Queensland, Australia
Toowoomba Hospital, Toowoomba, Queensland, Australia
Royal Hobart Hospital, Hobart, Tasmania, Australia
Ballarat Health Services, Ballarat, Victoria, Australia
Epworth HealthCare - Richmond, Richmond, Victoria, Australia
Border Medical Oncology, Wodonga, Victoria, Australia
Saint John of God Hospital Subiaco, Subiaco, Western Australia, Australia
St. Vincent's Hospital, Victoria Park, , Australia
Cross Cancer Institute, Edmonton, Alberta, Canada
BCCA - Fraser Valley Cancer Centre, Surrey, British Columbia, Canada
BCCA - Vancouver Cancer Centre, Vancouver, British Columbia, Canada
Horizon Health Network, Fredericton, New Brunswick, Canada
The Moncton Hospital, Moncton, New Brunswick, Canada
The Vitalite Health Network - Dr. Leon Richard, Moncton, New Brunswick, Canada
Regional Health Authority B, Zone 2, Saint John, New Brunswick, Canada
Cambridge Memorial Hospital, Cambridge, Ontario, Canada
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, Canada
Kingston Health Sciences Centre, Kingston, Ontario, Canada
Grand River Regional Cancer Centre, Kitchener, Ontario, Canada
Stronach Regional Health Centre at Southlake, Newmarket, Ontario, Canada
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Algoma District Cancer Program, Sault Ste. Marie, Ontario, Canada
Niagara Health System, St. Catharines, Ontario, Canada
Health Sciences North, Sudbury, Ontario, Canada
North York General Hospital, Toronto, Ontario, Canada
Humber River Regional Hospital, Toronto, Ontario, Canada
Michael Garron Hospital, Toronto, Ontario, Canada
University Health Network, Toronto, Ontario, Canada
Windsor Regional Cancer Centre, Windsor, Ontario, Canada
PEI Cancer Treatment Centre, Charlottetown, Prince Edward Island, Canada
Hopital de la Cite-de-la-Sante, Laval, Quebec, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
The Jewish General Hospital, Montreal, Quebec, Canada
CHU de Quebec-Hopital l'Enfant-Jesus (HEJ), Quebec City, Quebec, Canada
University Institute of Cardiology and, Quebec City, Quebec, Canada
Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada
Contact Details
Name: Natasha Leighl
Affiliation: Princess Margaret Hospital, Toronto, ON Canada
Role: STUDY_CHAIR
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