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Spots Global Cancer Trial Database for Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer

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Trial Identification

Brief Title: Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer

Official Title: Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer

Study ID: NCT04063501

Conditions

Lung Cancer

Study Description

Brief Summary: This study will prospectively collect airway, stool, and blood samples on 80 subjects with lung cancer undergoing immunotherapy. Investigators will evaluate airway/stool microbial signatures associated with local (lower airway) and systemic (blood) immune tone.They will then study whether microbiota and/or host signatures predict subjects' response by longitudinal assessment of the progression free survival. They will also repeat sampling after 8 weeks of immunotherapy to expand our mechanistic understanding of the response to treatment.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

NYU Langone Health, New York, New York, United States

Contact Details

Name: Leopoldo N Segal, MD, MSc

Affiliation: New York Langone Health

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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