Spots Global Cancer Trial Database for Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA
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Trial Identification
Brief Title: Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA
Official Title: Clinical Trials on Detection of Lung Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC and T Cells
Study ID: NCT03499678
Interventions
Study Description
Brief Summary: A central challenge in the fight against lung cancers is how to detect disease in a noninvasive manner before it is detectable by imaging methods. Although inroads have been made with more sensitive imaging techniques for earlier detection of breast and lung cancers, these techniques are limited by the size of lesion that could be detected. Alternatively, several blood proteomic biomarkers have been proposed but none offer as of yet sufficient predictive power. Consequently, effective non-invasive tools as prognostic indicators and biomarkers of lung cancer is urgently needed. The purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in PBMC and circulated tumor DNA in lung cancer patients.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Kazakh Institute of Oncology and Radiology, Almaty, , Kazakhstan
Contact Details
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