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Brief Title: Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer
Official Title: Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer
Study ID: NCT04063501
Brief Summary: This study will prospectively collect airway, stool, and blood samples on 80 subjects with lung cancer undergoing immunotherapy. Investigators will evaluate airway/stool microbial signatures associated with local (lower airway) and systemic (blood) immune tone.They will then study whether microbiota and/or host signatures predict subjects' response by longitudinal assessment of the progression free survival. They will also repeat sampling after 8 weeks of immunotherapy to expand our mechanistic understanding of the response to treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
NYU Langone Health, New York, New York, United States
Name: Leopoldo N Segal, MD, MSc
Affiliation: New York Langone Health
Role: PRINCIPAL_INVESTIGATOR