Spots Global Cancer Trial Database for Study of GRN163L With Paclitaxel and Carboplatin in Patients With Advanced or Metastatic Non Small Cell Lung Cancer
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Trial Identification
Brief Title: Study of GRN163L With Paclitaxel and Carboplatin in Patients With Advanced or Metastatic Non Small Cell Lung Cancer
Official Title: A Phase I Study of GRN163L in Combination With Paclitaxel and Carboplatin in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Study ID: NCT00510445
Conditions
Interventions
Study Description
Brief Summary: The purpose of this study is to determine the safety and the maximum tolerated dose (MTD) of GRN163L when administered in combination with a standard paclitaxel/carboplatin regimen to patients with advanced or metastatic non-small cell lung cancer.
Detailed Description: GRN163L is a telomerase template antagonist with in vitro and in vivo activity in a variety of tumor model systems. Telomerase is an enzyme that is active primarily in tumor cells and is crucial for the indefinite growth of tumor cells. Inhibition of telomerase may result in antineoplastic effects.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, United States
The University of Texas Southwestern Medical Center, Dallas, Texas, United States
UT MD Anderson Cancer Center, Houston, Texas, United States
University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, United States
Contact Details
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