Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Central Nervous System Depressants

All Drugs and Chemicals

Analgesics

Anesthetics

Propofol

Remifentanil

Desflurane

Hypnotics and Sedatives

Anesthetics, Intravenous

Anesthetics, General

Anesthetics, Inhalation

Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1\~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1\~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia.

Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.

desflurane

Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.

propofol

Eiichi Inada, M.D.

Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.

Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study

Arterial blood gases are monitored.Pulmonary blood flow is measured using transesophageal echocardiogram.

Time to extubation and orientation, where the patient is.

quality of consciousness will be assessed using Aldrete score

degree of nausea and frequency of vomiting

Baxter Healthcare Corporation

Juntendo University

Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1\~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

desflurane: Desflurane group: this group of patients receives desflurane as the main anesthetic agent during one-lung anesthesia.

Propofol group: this group of patients receives propofol as the main anesthetic agnet during on-lung anesthesia.

Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1\~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

propofol: Propofol group:this group of patients receives propofol as the main anesthetic agent during one-lung anesthesia.

Total

Age, Categorical

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Race and Ethnicity Not Collected

Japan

Region of Enrollment

Dr. Izumi Kawagoe

Preoperative

DLV(pre)

OLV(15min)

OLV(30min)

OLV(45min)

DLV(post)

5min after exT

30min after exT

60min after exT

Oxygenation

Rapidity of Emergence From Anesthesia

number of the patients who cannot achieve full consciousness in Aldlete score 5min after extubation

Quality of Consiousness

the number of patients who encountered PONV for 24 hours after surgery.

Spots Global Cancer Trial Database for Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

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