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Spots Global Cancer Trial Database for Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

Official Title: Evaluation of the Biological Effects of Broccoli Sprout Extract in Smokers

Study ID: NCT00255775

Conditions

Lung Cancer

Study Description

Brief Summary: RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of broccoli sprout extract may prevent lung cancer. PURPOSE: This clinical trial is studying how well broccoli sprout extract works in preventing lung cancer in smokers.

Detailed Description: OBJECTIVES: Primary * Evaluate the effect of broccoli sprout extract on levels of DNA adducts in participants who smoke. * Determine the effectiveness of broccoli sprout extract in reducing tobacco-carcinogen induced DNA adducts in these participants. Secondary * Determine the effects of broccoli sprout extract on markers of the Nrf2 pathway in these participants. * Determine the effectiveness of broccoli sprout extract, in increasing the activity of the Nrf2 pathway, in these participants. * Evaluate the feasibility of using lymphocytes and buccal cells to monitor DNA adducts and changes in the Nrf2 pathway in these participants. OUTLINE: Participants are stratified according to GST genotypic polymorphism (M1 vs T1). Participants receive oral broccoli sprout extract daily for 3 weeks. Participants keep a daily diary of their eating and smoking habits for 3 weeks before, during, and for 3 weeks after study treatment. They must continue to smoke during the study, but are encouraged to quit after completing the study treatment. PROJECTED ACCRUAL: A total of 70 participants will be accrued for this study.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Contact Details

Name: Julie Brahmer, MD

Affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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