Spots Global Cancer Trial Database for National Lung Screening Trial (NLST) Screening
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Trial Identification
Brief Title: National Lung Screening Trial (NLST) Screening
Official Title: National Lung Screening Trial A Randomized Trial Comparing Low-dose Helical CT With Chest Xray for Lung Cancer
Study ID: NCT00047385
Conditions
Study Description
Brief Summary: RATIONALE: Effective screening tests should help doctors detect lung cancer early and plan curative treatment. It is not yet known whether low-dose helical computed tomography (LDCT) screening is more effective than chest radiography (CXR) screening in reducing death from lung cancer. PURPOSE: Randomized clinical trial to compare the effectiveness of LDCT scan with that of CXR in screening individuals who are at high risk for developing lung cancer.
Detailed Description: OBJECTIVES: * Compare whether screening with low-dose helical CT scan vs chest x-ray reduces lung cancer-specific mortality in participants who are at high risk for developing lung cancer. OUTLINE: NLST participants were randomized to either low-dose helical CT or chest x-ray in equal proportions. A total of 53,454 participants were enrolled (26,722 in low-dose CT and 26,732 in chest radiography) at 33 screening centers across the United States. Screening was offered three times (at baseline and two annual follow-up examinations). The primary endpoint of the study was lung cancer mortality. The study arms were compared with regard to overall mortality, lung cancer incidence, and screening-related complications. All low-dose scanners and chest x-ray machines were certified for use and met NLST protocol requirements and American College of Radiology guidelines. Low-dose CT acquisitions and chest radiographs were interpreted by trained radiologists. Participants and their health care provider were informed of study examination results. Participants with abnormalities suspicious for lung cancer were contacted for information regarding diagnostic evaluation. Medical records were collected on diagnostic evaluation, medical complications, and initial treatment. Participants were then contacted at least annually by mail or telephone. The National Lung Screening Trial (NLST) represents the union of two NCI-sponsored efforts, the NCI Lung Screening Study and the American College of Radiology Imaging Network (ACRIN).
Eligibility
Minimum Age: 55 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
Univeristy of California, San Diego, La Jolla, California, United States
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States
University of Colorado Denver, Denver, Colorado, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
Mayo Clinic, Jacksonville, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Emory University School of Medicine, Atlanta, Georgia, United States
Pacific Health Research & Education Institute, Honolulu, Hawaii, United States
Northwestern University, Chicago, Illinois, United States
University of Iowa, Iowa City, Iowa, United States
Jewish Hopsital Heart and Lung Institute, Louisville, Kentucky, United States
Ochsner Medical Foundation Hospital, New Orleans, Louisiana, United States
Johns Hopkins University, Baltimore, Maryland, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Henry Ford Health System, Detroit, Michigan, United States
University of Minnesota School of Public Health, Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
Washington University School of Medicine, St. Louis, Missouri, United States
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Cancer Institute of New Jersey at Hamilton, Hamilton, New Jersey, United States
Wake Forest University, Winston-Salem, North Carolina, United States
St Elizabeth Health Center, Youngstown, Ohio, United States
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Brown University, Rhode Island Hospital, Providence, Rhode Island, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Vanderbilt University, Nashville, Tennessee, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
University of Utah Health Sciences Center, Salt Lake City, Utah, United States
Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States
Contact Details
Name: Christine D. Berg, MD
Affiliation: NCI - Early Detection Research Group
Role: STUDY_DIRECTOR
Name: Denise R. Aberle, MD
Affiliation: Jonsson Comprehensive Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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