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Spots Global Cancer Trial Database for Breathomics: May it Become an Affordable, New Tool for Early Diagnosis and Screening of Lung Cancer?

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Trial Identification

Brief Title: Breathomics: May it Become an Affordable, New Tool for Early Diagnosis and Screening of Lung Cancer?

Official Title: Breathomics: May it Become an Affordable, New Tool for Early Diagnosis and Screening of Lung Cancer? An Exploratory Study on a Cohort of 60 Patients

Study ID: NCT06034730

Conditions

Lung Cancer

Study Description

Brief Summary: Breath analysis examining specific patterns of volatile organic compounds (VOCs) has been demonstrated to be able to discriminate lung cancer (LC) patients from healthy controls (HC). However, the existing technology uses complex, expensive, and low throughput analytical platforms to give an offline response, thus preventing its applicability for mass screening. The reliability of a new portable device to enable rapid, on-site LC diagnosis is tested.

Detailed Description: The breath of patients with histologically proven NSCLC and healthy controls was sampled into Tedlar bags through a Nafion filter and a one-way mouthpiece. The breath samples in the bags were then analyzed by an automated micro portable gas chromatography device developed in-house, which consisted of a thermal desorption tube, thermal injector, separation column, and photoionization detector, as well as other accessories such as pumps, valves, and a helium cartridge. The chromatograms were analyzed by chemometrics and machine learning techniques.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Azienda Consorziale Ospedaliero-Universitaria Policlinico di Bari - Thoracic Surgery Unit, Bari, , Italy

Contact Details

Name: Giuseppe Marulli, MD, PhD

Affiliation: Humanitas Research Hospital

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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