Spots Global Cancer Trial Database for Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma
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Trial Identification
Brief Title: Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma
Official Title: A Pilot Study of Circulating Exosome RNA as Diagnostic and Prognostic Markers in Lung Metastases of Primary High-Grade Osteosarcoma
Study ID: NCT03108677
Interventions
Study Description
Brief Summary: The purpose of this study is to learn whether the profile of RNA from circulating exosomes can be used as a biomarker for lung metastases of primary high-grade osteosarcoma. Circulating exosomes plays roles in metastases in many kinds of cancer including osteosarcoma. By RNA profiling researchers may find lung metastases earlier than conventional work-up and predict the oncological outcomes.
Detailed Description: Investigators have performed a 4 patients pilot study under the oversight of hospital's ethics committee, and investigator found that the levels and mutations of circulating exosome RNA from patients with or without lung metastasis have significant differences. Then investigators wish to register this study to do a further research, in order to reveal the roles of circulating exosome RNA in metastases of osteosarcoma.
Eligibility
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ruijin Hospital Shanghai Jiao Tong University School of medicine, Shanghai, Shanghai, China
Contact Details
Name: Yuhui Shen, Ph.D., M.D.
Affiliation: Ruijin Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Weibin Zhang, Ph.D., M.D.
Affiliation: Ruijin Hospital
Role: PRINCIPAL_INVESTIGATOR
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