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Spots Global Cancer Trial Database for Afatinib in Lung Cancer With EGFR Mutation From Circulating Tumor DNA

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Trial Identification

Brief Title: Afatinib in Lung Cancer With EGFR Mutation From Circulating Tumor DNA

Official Title: A Phase II, Open-Label, Multicentre Study to Assess the Anti-tumour Activity of Afatinib in Patients With Activating Epidermal Growth Factor Receptor Mutation in Circulating Tumor DNA

Study ID: NCT02629523

Interventions

Afatinib

Study Description

Brief Summary: Treatment efficacy of afatinib will be assessed in patients with lung cancer harboring EGFR mutations which were detected from circulating tumor DNA.

Detailed Description: Obtaining Tumor tissue or cytology samples are not always available in some patients with lung cancer. Recently, studies showed that circulating tumor DNA can be used as a suitable substitute for mutation analysis. The sensitivity of EGFR mutation tests using circulating tumor DNA was reported in the range of 65.7% (10) to 75% (11), with high specificity and positive predictive value. In this trial, treatment efficacy of afatinib will be assessed in patients with NSCLC harboring EGFR mutations which were detected from circulating tumor DNA.

Keywords

Eligibility

Minimum Age: 19 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea, Republic of

Contact Details

Name: Young-Chul Kim, MD, PhD

Affiliation: Chonnam National University Hospital

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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