Spots Global Cancer Trial Database for Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
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Trial Identification
Brief Title: Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
Official Title: Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
Study ID: NCT01423747
Study Description
Brief Summary: With this protocol the ALL-SZT BFM international study group wants to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family or unrelated matched donors (MD) is equivalent to the HSCT from matched sibling donors (MSD). to evaluate the efficacy of haematopoietic stem cell transplantation (HSCT) from mismatched family or unrelated mismatched donors (MMD) as compared to HSCT from matched sibling donor (MSD) and matched donor (MD). to determine whether therapy has been carried out according to the main haematopoietic stem cell transplantation (HSCT) protocol recommendations. The standardisation of the treatment options during haematopoietic stem cell transplantation (HSCT) from different donor types aims at the achievement of an optimal comparison of survival after HSCT with survival after chemotherapy only. to prospectively evaluate and compare the incidence of acute and chronic graft- versus-host-disease (GvHD) after haematopoietic stem cell transplantation (HSCT) from matched sibling donor (MSD), from matched donor (MD) and from mismatched donor (MMD).
Detailed Description: Patients with high risk or relapsed acute lymphoblastic leukaemia (ALL) have a worse prognosis compared to all other patients with ALL. For these patients additional therapy approaches are required after they have achieved remission with multimodal chemotherapy. Allogeneic haematopoetic stem cell transplantation shows promising results mainly due to an immunological antileukaemic control by the graft-versus-leukaemia effect, but treatment related mortality and morbidity remains a serious problem.
Keywords
Eligibility
Minimum Age: 3 Months
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Universitätsklinik fßr Kinder- und Jugendheilkunde, Klin. Abt. f. Hämato-Onkologie, Graz, , Austria
Universitätsklinik fßr Kinder- und Jugendheilkunde, Innsbruck, , Austria
St. Anna Kinderspital, Vienna, , Austria
CharitÊ Campus Virchow- Klinikum, Klinikum der Pädiatrie, Onkologie/Hämatologie/KMT, Berlin, , Germany
Klinik und Poliklinik fßr Kinderheilkunde, Hämatologie, Onkologie, Dresden, , Germany
Universitätsklinikum Dßsseldorf, Klinik f. Kinderonkologie, Hämatologie u. Immunologie, Dßsseldorf, , Germany
Klinik fßr Kinder und Jugendliche der Universität Erlangen-Nßrnberg, Erlangen, , Germany
Universitätsklinikum Essen, Zentrum fßr Kinderheilkunde, Abt. fßr Hämatologie/Onkologie, Essen, , Germany
Klinik fßr Kinderheilkunde III, Hämatologie und Onkologie, Johann Wolfgang Goethe Universität, Frankfurt am Main, , Germany
Universitätsklinikum Freiburg, Zentrum fßr Kinderheilkunde und Jugendmedizin, Klinik IV: Päd. Hämatologie und Onkologie, Freiburg, , Germany
Zentrum fßr Kinderheilkunde, Abt. Hämatologie und Onkologie, Giessen, , Germany
Klinkum der Med. Fakultät der Martin-Luther-Universität Halle-Wittenberg, Uni. Klinik un Poliklinik fßr Kinder- und Jugendmedizin, Halle, , Germany
Universitätsklinikum Hamburg-Eppendorf, Kinderklinik, Abt. fßr Hämatologie und Onkologie, Hamburg, , Germany
Med. Hochschule Hannover, Päd. Hämatologie und Onkologie, Hannover, , Germany
Universitätskinderklinik, Päd. Hämatologie, Onkologie und Immunologie, Heidelberg, , Germany
Klinik fĂźr Knochenmarktransplantation, Idar-Oberstein, , Germany
Klinik fĂźr Kinder- und Jugendmedizin, Jena, , Germany
Universitätsklinikum Kiel, Klinik fßr Allgemeine Pädiatrie, Kiel, , Germany
Klinikum der Universität Mßnchen, Dr. von Haunersches Kinderspital, Abt. fßr Hämatologie / Onkologie, Mßnchen, , Germany
Städt. Krankenhaus Mßnchen-Schwabing, Universitätskinderklinik der TU, Mßnchen, , Germany
Universitätsklinikum Mßnster, Klinik und Poliklinik fßr Kinderheilkunde, päd. Hämatologie / Onkologie, Mßnster, , Germany
Univ.-Klinik fĂźr Kinderheilkunde und Jugendmedizin, TĂźbingen, , Germany
Universitätskinderklinik, Ulm, , Germany
Universitätsklinik, päd. Onkologie/Stammzelltransplantation, Wßrzburg, , Germany
Contact Details
Name: Arend v. Stackelberg, MD, PhD
Affiliation: ALL-REZ BFM Study Center Berlin Germany
Role: STUDY_CHAIR
Name: Martin Schrappe, MD, Prof.
Affiliation: ALL BFM study center Kiel, Germany
Role: STUDY_CHAIR
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