Spots Global Cancer Trial Database for A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
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Trial Identification
Brief Title: A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)
Official Title: An Open-Label, Multicenter, Phase I/II Trial Evaluating the Safety, Efficacy, and Pharmacokinetics of Escalating Doses of Mosunetuzumab (BTCT4465A) as a Single Agent and Combined With Atezolizumab in Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia
Study ID: NCT02500407
Study Description
Brief Summary: This is a Phase 1/2 dose-escalation study of BTCT4465A (Mosunetuzumab) administered as a single agent and in combination with atezolizumab in participants with relapsed or refractory B-cell NHL and CLL. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope National Medical Center, Duarte, California, United States
University of California San Diego Moores Cancer Center, La Jolla, California, United States
Sansum Medical Clinic, Inc., Santa Barbara, California, United States
Rocky Mountain Cancer Center, Denver, Colorado, United States
Yale University School Of Medicine, New Haven, Connecticut, United States
Washington University; Wash Uni. Sch. Of Med, Saint Louis, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States
Memorial Sloan Kettering Cancer Center - Commack, Commack, New York, United States
Memorial Sloan-Kettering Cancer Center, Commack, New York, United States
Memorial Sloan Kettering Cancer Center at Westchester, Harrison, New York, United States
New York Uni Medical Center, New York, New York, United States
Willamette Valley Cancer Insitute and Research Center, Springfield, Oregon, United States
University of Pennsylvania; School of Medicine, Philadelphia, Pennsylvania, United States
Tennessee Oncology - Nashville, Nashville, Tennessee, United States
MD Anderson Cancer Center, Houston, Texas, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
Wollongong Hospital; Cancer Care Centre, Wollongong, New South Wales, Australia
Icon Cancer Care South Brisbane, South Brisbane, Queensland, Australia
Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Royal Adelaide Hospital; Haematology Clinical Trials, Adelaide, South Australia, Australia
St. Vincent's Hospital Melbourne, Fitzroy, South Australia, Australia
Royal Hobart Hospital, Hobart, Tasmania, Australia
Monash Health Clinical Trial Pharmacy department, Clayton, Victoria, Australia
The Alfred, Melbourne, Victoria, Australia
Linear Clinical Research Limited, Nedlands, Western Australia, Australia
The Perth Blood Institute, Nedlands, Western Australia, Australia
BC Cancer Agency Vancouver Centre - PARENT, Vancouver, British Columbia, Canada
Princess Margaret Hospital; Department of Med Oncology, Toronto, Ontario, Canada
Jewish General Hospital; Research Unit, Montréal, Quebec, Canada
DIAKO Ev. Diakonie-Krankenhaus Bremen GmbH; Med. Klinik II; Hämatologie und internistische Onkologie, Bremen, , Germany
St. Johannes Hospital; Abt. für Hämatologie und Onkologie, Dortmund, , Germany
Universitätsklinikum Heidelberg, Heidelberg, , Germany
Universitatsklinikum Koln; Apotheke Uniklinik Koln, Koln, , Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz, Mainz, , Germany
Klinikum der Universität München, Campus Großhadern; Medizinische Klinik und Poliklinik III, München, , Germany
Universitatsklinikum Munster, Münster, , Germany
Universitätsklinikum Würzburg, Würzburg, , Germany
Seoul National University Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Hospital Universitario Vall d Hebron, Barcelona, , Spain
Hospital Universitario La Paz, Madrid, , Spain
Complejo Asistencial Universitario de Salamanca, Salamanca, , Spain
Barts Cancer Institute, London, , United Kingdom
The Christie NHS Foundation Trust, Manchester, , United Kingdom
Royal Marsden Hospital; Institute of Cancer Research; Pharmacy Stores, Sutton, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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