Spots Global Cancer Trial Database for A Study of Rituximab and Bevacizumab in Patients With Follicular Non-Hodgkin's Lymphoma
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Trial Identification
Brief Title: A Study of Rituximab and Bevacizumab in Patients With Follicular Non-Hodgkin's Lymphoma
Official Title: Rituximab +/- Bevacizumab in the Treatment of Patients With Follicular Non-Hodgkin's Lymphoma: A Randomized, Phase II Trial
Study ID: NCT00193492
Conditions
Study Description
Brief Summary: The purpose of this study is to assess the feasibility, efficacy and safety of adding bevacizumab to rituximab compared to rituximab alone in patients with previously treated follicular non-hodgkin's lymphoma (NHL) whose disease has progressed following at least one previous chemotherapy regimen and not more than 2 previous chemotherapy regimens.
Detailed Description: Upon determination of eligibility, patients will randomly be assigned to one of two treatment arms: * Rituximab * Rituximab + bevacizumab For every 2 patients randomized, 1 will receive treatment number 1 (rituximab), and 1 patient will receive treatment number 2 (rituximab + bevacizumab). This is not a blinded study, so both the patient and doctor will know which treatment has been assigned.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Northeast Arkansas Clinic, Jonesboro, Arkansas, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Integrated Community Oncology Network, Jacksonville, Florida, United States
Watson Clinic for Cancer Research, Lakeland, Florida, United States
Florida Hospital Cancer Institute, Orlando, Florida, United States
Medical Oncology Associates of Augusta, Augusta, Georgia, United States
Northeast Georgia Medical Center, Gainesville, Georgia, United States
Wellstar Cancer Research, Marietta, Georgia, United States
Providence Medical Group, Terre Haute, Indiana, United States
Graves-Gilbert Clinic, Bowling Green, Kentucky, United States
Baptist Hospital East, Louisville, Kentucky, United States
Norton Cancer Institute, Louisville, Kentucky, United States
Hematology Oncology Clinic, LLP, Baton Rouge, Louisiana, United States
Center for Cancer and Blood Disorders, Bethesda, Maryland, United States
National Capital Clinical Research Consortium, Bethesda, Maryland, United States
Methodist Cancer Center, Omaha, Nebraska, United States
Hematology Oncology Associates of Northern NJ, Morristown, New Jersey, United States
Oncology Hematology Care, Cincinnati, Ohio, United States
Berks Hematology Oncology Associates, West Reading, Pennsylvania, United States
Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States
Chattanooga Oncology Hematology Associates, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Contact Details
Name: John D Hainsworth, MD
Affiliation: SCRI Development Innovations, LLC
Role: PRINCIPAL_INVESTIGATOR
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