Spots Global Cancer Trial Database for Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP
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Trial Identification
Brief Title: Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP
Official Title: A Prospective Multicenter Phase 2 Study of the Chemotherapy-light Combination of Intravenous Rituximab With the Antibody-drug Conjugate Polatuzumab Vedotin and the Bispecific Antibody Glofitamab in Previously Untreated Aggressive B-cell Lymphoma Patients Above 60 Years of Age Ineligible for a Fully Dosed R-CHOP
Study ID: NCT05798156
Conditions
Study Description
Brief Summary: In the present trial the chemotherapy- light treatment concept R-Pola-Glo will be evaluated that combines the anti-CD20 antibody rituximab (R) with the ADC polatuzumab vedotin (Pola) and the (BiMabs) glofitamab (Glo) in elderly and/or medical unfit and previously untreated patients with aggressive B-cell lymphoma. The outcome and feasibility data obtained here will be used for further clinical development of this new chemolight triple combination.
Detailed Description:
Keywords
Eligibility
Minimum Age: 61 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Kepler Universitätsklinikum, Linz, , Austria
Ordensklinikum Linz - Barmherzige Schwestern, Linz, , Austria
Ordensklinikum Linz - Elisabethinen, Linz, , Austria
Landeskrankenhaus Salzburg Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Salzburg, , Austria
Univ. Klinikum St. Pölten, St. Pölten, , Austria
AKH Meduni Wien, Wien, , Austria
Hanusch Krankenhaus, Wien, , Austria
Charité - Universitätsmedizin Berlin, Berlin, , Germany
HELIOS Klinikum Berlin-Buch, Berlin, , Germany
Medizinisches Universitätsklinikum Knappschaftskrankenhaus Bochum, Bochum, , Germany
Klinikum Chemnitz, Chemnitz, , Germany
Universitätsklinikum Erlangen, Erlangen, , Germany
Ev. Klinikum Essen-Mitte, Essen, , Germany
Universitätsklinikum Halle, Halle, , Germany
University Hospital Jena, Jena, , Germany
Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, , Germany
Universitätsklinikum Leipzig, Leipzig, , Germany
Klinikum Ludwigshafen, Ludwigshafen, , Germany
TU München (rechts des Isar), München, , Germany
Unversitätsklinikum Münster, Münster, , Germany
Ortenauklinikum Offenburg-Kehl, Offenburg, , Germany
Universitätsklinikum Regensburg, Regensburg, , Germany
Kreiskliniken Reutlingen, Reutlingen, , Germany
Universitätsklinikum Würzburg, Würzburg, , Germany
Contact Details
Name: Salah-Eddin Al-Batran, Prof. Dr.
Affiliation: Institut fuer Klinische Krebsforschung IKF GmbH
Role: STUDY_CHAIR
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