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Spots Global Cancer Trial Database for Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

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Trial Identification

Brief Title: Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Official Title: Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR): A Phase II Basket Trial

Study ID: NCT03297606

Study Description

Brief Summary: Cancer drugs which target the effects of abnormal gene changes are called 'targeted therapies'. This study, called PM.1 or CAPTUR, will include some targeted therapies that are currently available. The purpose of this study is to find out what are the effects on a patient and their cancer when they are given a targeted therapy drug that is specific to an abnormal gene change in their cancer.

Detailed Description: Recent advances in laboratory technology have enabled the identification of changes in the genetic makeup of tumors that might be responsible for their malignant behavior such as uncontrolled growth and spread. Some of these changes can be 'druggable', i.e. there may be cancer medicines that can specifically act on the tumour's genetic abnormality. Several cancer centers and programs have initiated this type of molecular profiling across Canada, with the goal to identify 'druggable' changes in tumors to find matching therapy for patients. These include initiatives in British Columbia, Ontario and Quebec. The CAnadian Profiling and Targeted agent Utilization tRial (CAPTUR) will test the activity of a list of commercially available targeted agents in patients who have undergone tumor profiling and have 'druggable' changes identified in their cancers.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cross Cancer Institute, Edmonton, Alberta, Canada

BCCA - Cancer Centre for the Southern Interior, Kelowna, British Columbia, Canada

BCCA - Vancouver Cancer Centre, Vancouver, British Columbia, Canada

Kingston Health Sciences Centre, Kingston, Ontario, Canada

London Regional Cancer Program, London, Ontario, Canada

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

University Health Network, Toronto, Ontario, Canada

The Jewish General Hospital, Montreal, Quebec, Canada

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Contact Details

Name: Lillian Siu

Affiliation: Univ. Health Network-OCI/Princess Margaret Hospital, Toronto, ON Canada

Role: STUDY_CHAIR

Name: Daniel J Renouf

Affiliation: BCCA - Vancouver Cancer Centre, Vancouver BC, Canada

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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