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Spots Global Cancer Trial Database for A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

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Trial Identification

Brief Title: A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Official Title: A Prospective Multicenter Cohort Study on the Efficacy and Safety of Stratified Treatment of Chinese Children With Lymphoblastic Lymphoma Based on Risk Factors

Study ID: NCT03971318

Interventions

Study Description

Brief Summary: With the development of molecular biology and precise medical treatment, new challenges have been raised in the diagnosis and treatment of non-Hodgkin lymphoma (NHL) in children. In recent years, the criteria for clinical staging and efficacy evaluation of NHL in children have been updated. Recent clinical studies of COG in the United States and LMB in France have confirmed that molecular biological markers such as Notch1, PTEN and LOH6q are significantly associated with the prognosis of T-lymphoblastic lymphoma (T-LBL). These molecular biological markers should be included in the new risk stratification system. High-intensity treatment of high-risk patients will improve survival. Recent studies have also suggested that PET/CT is helpful in evaluating residual lesions in patients with lymphoma after chemotherapy. In order to keep pace with the times in the diagnosis, clinical staging, risk stratification, efficacy evaluation and treatment of NHL in children. SCCCG-LBL-2017 was formulated by South China Children's Cancer Group of Non-Hodgkin lymphoma, which mainly updated in clinical staging, efficacy evaluation, risk stratification, treatment,etc..

Detailed Description: Research purpose: 1. To investigate the efficacy and safety of SCCCG-LBL-2017 in Chinese children with LBL. 2. To explore the feasibility of risk stratification of T-LBL by combining genotyping. 3. To investigate the correlation between MDD and MRD in lymphoblastic lymphoma and prognosis. 4. To investigate the role of PET/CT in the assessment of residual lymphoblastic lymphoma. 5. To explore the effect of reducing HD-MTX dosage and shortening maintenance therapy time on the efficacy and survival of low-risk LBL patients. 6. To explore the effect of prolonging the duration of maintenance therapy on the efficacy and survival of high-risk LBL patients.

Keywords

Eligibility

Minimum Age: 1 Year

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

Contact Details

Name: Zhen zijun

Affiliation: Sun Yat-sen University

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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