Spots Global Cancer Trial Database for S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma

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Trial Identification

Brief Title: S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma

Official Title: Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma

Study ID: NCT00985699

Conditions

Lymphoma

Interventions

polymorphism analysis

laboratory biomarker analysis

pharmacogenomic studies

Study Description

Brief Summary: RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.

Detailed Description: OBJECTIVES: * To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1). * To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma. OUTLINE: Previously collected samples are used for biomarker analysis.