Spots Global Cancer Trial Database for Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
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Trial Identification
Brief Title: Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
Official Title: A Multi-Stage Randomized Phase II Study of Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
Study ID: NCT02436707
Conditions
Study Description
Brief Summary: The purpose of this study is to find out what effects new combinations of treatment will have this disease. New promising treatment strategies will be added to this study as they are available to be compared against the standard treatment.
Detailed Description: This research is being done to try to find new combinations of treatment that may be better for treating patients with this disease. It is not clear however if these treatments can offer better results than standard treatment. The study uses a "pick the winner" design to facilitate efficient screening of novel combination treatment regimens and select those meeting pre-specified criteria for testing in the phase III setting. All novel treatment options will be compared against the standard treatment for this disease: rituximab plus gemcitabine, dexemthasone, and cisplatin (R-GDP).
Keywords
Eligibility
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Cross Cancer Institute, Edmonton, Alberta, Canada
BCCA - Vancouver Cancer Centre, Vancouver, British Columbia, Canada
CancerCare Manitoba, Winnipeg, Manitoba, Canada
QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, Canada
Kingston Health Sciences Centre, Kingston, Ontario, Canada
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Odette Cancer Centre, Toronto, Ontario, Canada
University Health Network, Toronto, Ontario, Canada
CIUSSS de l'Est-de-I'lle-de-Montreal, Montreal, Quebec, Canada
CHUM-Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
CHU de Quebec-Hopital l'Enfant-Jesus (HEJ), Quebec City, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Contact Details
Name: Michael Crump
Affiliation: Univ. Health Network-OCI/Princess Margaret Hospital, Toronto ON Canada
Role: STUDY_CHAIR
Name: John Kuruvilla
Affiliation: Univ. Health Network-Princess Margaret Hospital, Toronto ON Canada
Role: STUDY_CHAIR
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