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Spots Global Cancer Trial Database for Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery

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Trial Identification

Brief Title: Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery

Official Title: Randomized Phase III Trial of Paclitaxel +Trastuzumab + Lapatinib Versus Paclitaxel + Trastuzumab as Neoadjuvant Treatment of HER2-Positive Primary Breast Cancer

Study ID: NCT00770809

Study Description

Brief Summary: This randomized phase III trial studies paclitaxel and trastuzumab with or without lapatinib to see how well they work in treating patients with stage II or stage III breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel with trastuzumab and/or lapatinib before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known which regimen is more effective in treating patients with breast cancer.

Detailed Description: PRIMARY OBJECTIVE: I. To determine if the pathologic complete response (pCR) in the breast to neoadjuvant weekly paclitaxel with trastuzumab plus lapatinib (THL) is 20% greater than the pCR to weekly paclitaxel with trastuzumab alone (TH). SECONDARY OBJECTIVES: I. To determine the pathologic complete response in the breast and axilla, using American Joint Committee on Cancer (AJCC) Tumor, Lymph Nodes and Metastasis (TMN) criteria (version 6), to neoadjuvant weekly paclitaxel plus human epidermal growth factor 2 (HER2)- targeted therapy in patients with HER2-positive operable breast cancer. II. To evaluate residual cancer burden (RCB) as a predictor of long term relapse free survival (RFS) and overall survival (OS). III. To document the toxicity of all chemotherapeutic regimens (THL, TH). IV. To determine the correlation between clinical, radiographic and pathologic response. V. To compare overall survival (OS), relapse free survival (RFS) and time to first failure (TFF) among the treatment groups. VI. To obtain blood, fresh frozen and fixed tumor tissue to test specific hypotheses for which biomarker data exist and to evaluate biomarkers in blood, serum and tissue that are likely to influence response to and toxicity of trastuzumab alone or trastuzumab plus lapatinib, when given with paclitaxel. VII. To determine the surgical practice patterns for breast conservation and sentinel lymphadenectomy in patients undergoing neoadjuvant chemotherapy. VIII. To determine the radiotherapy practice patterns for post-mastectomy and regional nodal irradiation in patients undergoing neoadjuvant chemotherapy. IX. To evaluate pharmacogenomic determinants of toxicity. OUTLINE: Patients are randomized to 1 of 3 treatment arms. ARM I: Patients receive trastuzumab IV over 30-90 minutes and paclitaxel IV over 1 hour once weekly and lapatinib ditosylate orally (PO) once daily for 16 weeks in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive trastuzumab and paclitaxel as in arm I. ARM III: Patients receive paclitaxel and lapatinib ditosylate as in arm I. (Discontinued as of 6-15-11) Within 42 days after completion of neoadjuvant therapy, patients in both arms undergo definitive surgery (breast conservation or total mastectomy). After completion of study treatment, patients are followed every 6 months for 2 years and then annually for up to 10 years.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Banner University Medical Center - Tucson, Tucson, Arizona, United States

Sparks Regional Medical Center, Fort Smith, Arkansas, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States

East Bay Radiation Oncology Center, Castro Valley, California, United States

Eden Hospital Medical Center, Castro Valley, California, United States

Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, United States

Bay Area Breast Surgeons Inc, Emeryville, California, United States

Valley Medical Oncology Consultants-Fremont, Fremont, California, United States

Contra Costa Regional Medical Center, Martinez, California, United States

El Camino Hospital, Mountain View, California, United States

Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States

Highland General Hospital, Oakland, California, United States

Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States

Bay Area Tumor Institute, Oakland, California, United States

Hematology and Oncology Associates-Oakland, Oakland, California, United States

Tom K Lee Inc, Oakland, California, United States

Desert Regional Medical Center, Palm Springs, California, United States

Palo Alto Medical Foundation Health Care, Palo Alto, California, United States

Valley Care Health System - Pleasanton, Pleasanton, California, United States

Valley Medical Oncology Consultants, Pleasanton, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Saint Helena Hospital, Saint Helena, California, United States

Salinas Valley Memorial, Salinas, California, United States

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

UCSF Medical Center-Mount Zion, San Francisco, California, United States

Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, United States

The Medical Center of Aurora, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

SCL Health Saint Joseph Hospital, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Western States Cancer Research NCORP, Denver, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, United States

Banner North Colorado Medical Center, Greeley, Colorado, United States

Saint Anthony Hospital, Lakewood, Colorado, United States

Littleton Adventist Hospital, Littleton, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Longmont United Hospital, Longmont, Colorado, United States

Banner McKee Medical Center, Loveland, Colorado, United States

Parker Adventist Hospital, Parker, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

North Suburban Medical Center, Thornton, Colorado, United States

SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Manchester Memorial Hospital, Manchester, Connecticut, United States

Middlesex Hospital, Middletown, Connecticut, United States

Beebe Medical Center, Lewes, Delaware, United States

Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States

MedStar Georgetown University Hospital, Washington, District of Columbia, United States

Halifax Health Medical Center-Centers for Oncology, Daytona Beach, Florida, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

Florida Cancer Specialists-Gainesville Cancer Center, Gainesville, Florida, United States

Jupiter Medical Center, Jupiter, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

Cleveland Clinic-Weston, Weston, Florida, United States

Piedmont Hospital, Atlanta, Georgia, United States

Atlanta Regional CCOP, Atlanta, Georgia, United States

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

WellStar Cobb Hospital, Austell, Georgia, United States

John B Amos Cancer Center, Columbus, Georgia, United States

Dekalb Medical Center, Decatur, Georgia, United States

Piedmont Fayette Hospital, Fayetteville, Georgia, United States

Northside Hospital - Gwinnett, Lawrenceville, Georgia, United States

Atrium Health Navicent, Macon, Georgia, United States

Wellstar Kennestone Hospital, Marietta, Georgia, United States

Southern Regional Medical Center, Riverdale, Georgia, United States

Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Anthony's Health, Alton, Illinois, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

Presence Resurrection Medical Center, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Weiss Memorial Hospital, Chicago, Illinois, United States

Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States

Duly Health and Care Joliet, Joliet, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Advocate Christ Medical Center, Oak Lawn, Illinois, United States

Swedish American Hospital, Rockford, Illinois, United States

Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, United States

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana, United States

Reid Health, Richmond, Indiana, United States

McFarland Clinic - Ames, Ames, Iowa, United States

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf, Iowa, United States

Mission Cancer and Blood - West Des Moines, Clive, Iowa, United States

Mercy Capitol, Des Moines, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Iowa-Wide Oncology Research Coalition NCORP, Des Moines, Iowa, United States

Mission Cancer and Blood - Des Moines, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Mission Cancer and Blood - Laurel, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Siouxland Regional Cancer Center, Sioux City, Iowa, United States

Mercy Medical Center-Sioux City, Sioux City, Iowa, United States

Saint Luke's Regional Medical Center, Sioux City, Iowa, United States

HaysMed, Hays, Kansas, United States

Hutchinson Regional Medical Center, Hutchinson, Kansas, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Ascension Via Christi - Pittsburg, Pittsburg, Kansas, United States

Salina Regional Health Center, Salina, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, United States

University of Kansas Health System Saint Francis Campus, Topeka, Kansas, United States

Harold Alfond Center for Cancer Care, Augusta, Maine, United States

Eastern Maine Medical Center, Bangor, Maine, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

Christiana Care - Union Hospital, Elkton, Maryland, United States

TidalHealth Peninsula Regional, Salisbury, Maryland, United States

Holy Cross Hospital, Silver Spring, Maryland, United States

Sturdy Memorial Hospital, Attleboro, Massachusetts, United States

Tufts Medical Center, Boston, Massachusetts, United States

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

Brigham and Women's Hospital, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Steward Saint Elizabeth's Medical Center, Brighton, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts, United States

Newton-Wellesley Hospital, Newton, Massachusetts, United States

Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Beaumont Hospital - Dearborn, Dearborn, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States

Genesys Regional Medical Center, Grand Blanc, Michigan, United States

Allegiance Health, Jackson, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

University of Michigan Health - Sparrow Lansing, Lansing, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, United States

Lake Huron Medical Center, Port Huron, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota, United States

Southeast Missouri Hospital, Cape Girardeau, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Southeast Cancer Center, Cape Girardeau, Missouri, United States

MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri, United States

University Health Truman Medical Center, Kansas City, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Center for Cancer Care and Research, Saint Louis, Missouri, United States

Comprehensive Cancer Care PC, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Northern Rockies Radiation Oncology Center, Billings, Montana, United States

Saint Vincent Healthcare, Billings, Montana, United States

Montana Cancer Consortium NCORP, Billings, Montana, United States

Saint Vincent Frontier Cancer Center, Billings, Montana, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States

Benefis Sletten Cancer Institute, Great Falls, Montana, United States

Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Northern Montana Hospital, Havre, Montana, United States

Saint Peter's Community Hospital, Helena, Montana, United States

Glacier Oncology PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Specialists, Missoula, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Community Medical Center, Missoula, Montana, United States

Guardian Oncology and Center for Wellness, Missoula, Montana, United States

Nebraska Cancer Research Center, Lincoln, Nebraska, United States

Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States

Alegent Health Lakeside Hospital, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire, United States

Cheshire Medical Center-Dartmouth-Hitchcock Keene, Keene, New Hampshire, United States

LRGHealthcare-Lakes Region General Hospital, Laconia, New Hampshire, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Dartmouth Cancer Center - Manchester, Manchester, New Hampshire, United States

Elliot Hospital, Manchester, New Hampshire, United States

Solinsky Center for Cancer Care, Manchester, New Hampshire, United States

Foundation Medical Partners, Nashua, New Hampshire, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

Morristown Medical Center, Morristown, New Jersey, United States

Rutgers New Jersey Medical School, Newark, New Jersey, United States

Overlook Hospital, Summit, New Jersey, United States

Lovelace Medical Center-Saint Joseph Square, Albuquerque, New Mexico, United States

Hematology Oncology Associates, Albuquerque, New Mexico, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

Elmhurst Hospital Center, Elmhurst, New York, United States

Queens Hospital Center, Jamaica, New York, United States

Northwell Health NCORP, Lake Success, New York, United States

Northwell Health/Center for Advanced Medicine, Lake Success, New York, United States

North Shore University Hospital, Manhasset, New York, United States

Garnet Health Medical Center, Middletown, New York, United States

Long Island Jewish Medical Center, New Hyde Park, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Vassar Brothers Medical Center, Poughkeepsie, New York, United States

State University of New York Upstate Medical University, Syracuse, New York, United States

Mission Hospital, Asheville, North Carolina, United States

Cone Health Cancer Center at Alamance Regional, Burlington, North Carolina, United States

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States

Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina, United States

Duke University Medical Center, Durham, North Carolina, United States

Wayne Memorial Hospital, Goldsboro, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

ECU Health Oncology Kinston, Kinston, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, United States

UNC Rex Healthcare, Raleigh, North Carolina, United States

Marion L Shepard Cancer Center - ECU Health Beaufort Hospital, Washington, North Carolina, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Mid Dakota Clinic, Bismarck, North Dakota, United States

Saint Alexius Medical Center, Bismarck, North Dakota, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Cleveland Clinic Akron General, Akron, Ohio, United States

Cleveland Clinic Cancer Center Beachwood, Beachwood, Ohio, United States

Aultman Health Foundation, Canton, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Grandview Hospital, Dayton, Ohio, United States

Good Samaritan Hospital - Dayton, Dayton, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Dayton NCI Community Oncology Research Program, Dayton, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Cleveland Clinic Cancer Center Independence, Independence, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Saint Rita's Medical Center, Lima, Ohio, United States

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States

University Hospitals Parma Medical Center, Parma, Ohio, United States

Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States

Greene Memorial Hospital, Xenia, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Cancer Care Associates, Oklahoma City, Oklahoma, United States

UPMC Hillman Cancer Center Erie, Erie, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

Lewistown Hospital, Lewistown, Pennsylvania, United States

Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania, United States

Mount Nittany Medical Center, State College, Pennsylvania, United States

Kent Hospital, Warwick, Rhode Island, United States

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, United States

Roper Hospital, Charleston, South Carolina, United States

Prisma Health Cancer Institute - Easley, Easley, South Carolina, United States

Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Butternut, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States

Prisma Health Greenville Memorial Hospital, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States

Self Regional Healthcare, Greenwood, South Carolina, United States

Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States

Lexington Medical Center, West Columbia, South Carolina, United States

Erlanger Medical Center, Chattanooga, Tennessee, United States

Nashville Oncology Associates PC, Nashville, Tennessee, United States

Meharry Medical College, Nashville, Tennessee, United States

Doctor's Hospital of Laredo, Laredo, Texas, United States

Texas Tech University Health Sciences Center-Lubbock, Lubbock, Texas, United States

Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont, United States

University of Vermont and State Agricultural College, Burlington, Vermont, United States

Danville Regional Medical Center, Danville, Virginia, United States

Hematology Oncology Associates of Fredericksburg Inc, Fredericksburg, Virginia, United States

Centra Alan B Pearson Regional Cancer Center, Lynchburg, Virginia, United States

Cancer Care Center at Island Hospital, Anacortes, Washington, United States

MultiCare Auburn Medical Center, Auburn, Washington, United States

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, United States

Highline Medical Center-Main Campus, Burien, Washington, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Saint Francis Hospital, Federal Way, Washington, United States

Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States

EvergreenHealth Medical Center, Kirkland, Washington, United States

Saint Clare Hospital, Lakewood, Washington, United States

Skagit Valley Hospital, Mount Vernon, Washington, United States

Providence - Saint Peter Hospital, Olympia, Washington, United States

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, United States

MultiCare Good Samaritan Hospital, Puyallup, Washington, United States

Virginia Mason Medical Center, Seattle, Washington, United States

Minor and James Medical PLLC, Seattle, Washington, United States

Pacific Medical Center-First Hill, Seattle, Washington, United States

Kaiser Permanente Washington, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

University of Washington Medical Center - Montlake, Seattle, Washington, United States

PeaceHealth United General Medical Center, Sedro-Woolley, Washington, United States

Cancer Care Northwest - Spokane South, Spokane, Washington, United States

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, United States

Providence Holy Family Hospital, Spokane, Washington, United States

Evergreen Hematology and Oncology PS, Spokane, Washington, United States

MultiCare Allenmore Hospital, Tacoma, Washington, United States

MultiCare Tacoma General Hospital, Tacoma, Washington, United States

Northwest NCI Community Oncology Research Program, Tacoma, Washington, United States

Saint Joseph Medical Center, Tacoma, Washington, United States

Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, United States

Saint Mary's Medical Center, Huntington, West Virginia, United States

Camden Clark Medical Center, Parkersburg, West Virginia, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Ascension Southeast Wisconsin Hospital - Saint Joseph Campus, Milwaukee, Wisconsin, United States

Welch Cancer Center, Sheridan, Wyoming, United States

San Juan City Hospital, San Juan, , Puerto Rico

Contact Details

Name: Lisa A Carey

Affiliation: Alliance for Clinical Trials in Oncology

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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