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Brief Title: Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies
Official Title: A Phase I Study of Intravenous (IV) Palifosfamide-tris Administered in Combination With IV Etoposide and IV Carboplatin in Patients With Malignancies for Which Etoposide and Carboplatin Are an Appropriate Choice
Study ID: NCT01242072
Brief Summary: This an an open-label study to define the safety profile and the maximum tolerated dose and confirm the clinical effective dose of palifosfamide-tris given intravenously in combination with etoposide and carboplatin in a wide range of cancers which etoposide and carboplatin are normally given. Once the maximum dose of palifosfamide-tris is determined,a Phase II study using the 3 agents combined will begin.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Indiana University Simon Cancer Center, Indianapolis, Indiana, United States
Horizon Oncology Research, Lafayette, Indiana, United States
Medical Consultants, PC, Muncie, Indiana, United States
Washington University, St. Louis, Missouri, United States