Spots Global Cancer Trial Database for Phase 1/2 Study of the Combination of Pixantrone, Etoposide, Bendamustine and, in CD20 Positive Tumors, Rituximab in Patients With Relapsed Aggressive Non-Hodgkin Lymphomas of B- or T-cell Phenotype - the P[R]EBEN Study
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Trial Identification
Brief Title: Phase 1/2 Study of the Combination of Pixantrone, Etoposide, Bendamustine and, in CD20 Positive Tumors, Rituximab in Patients With Relapsed Aggressive Non-Hodgkin Lymphomas of B- or T-cell Phenotype - the P[R]EBEN Study
Official Title: Phase 1/2 Study of the Combination of Pixantrone, Etoposide, Bendamustine and, in CD20 Positive Tumors, Rituximab in Patients With Relapsed Aggressive Non-Hodgkin Lymphomas of B- or T-cell Phenotype - the P[R]EBEN Study
Study ID: NCT02678299
Conditions
Interventions
Study Description
Brief Summary: This is a phase 1/2 open label study to assess the safety and efficacy of pixantrone in combination with bendamustine, etoposide and , for CD20 positive B-cell lymphomas, rituximab (P\[R\]EBEN), in patients with relapsed aNHL of B- or T-cell phenotype.
Detailed Description: This is a phase 1/2 open label study to assess the safety and efficacy of pixantrone in combination with bendamustine, etoposide and , for CD20 positive B-cell lymphomas, rituximab (P\[R\]EBEN), in patients with relapsed aNHL of B- or T-cell phenotype.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Hematology, Aarhus University Hospital, Aarhus, , Denmark
Department of Hematology, Copenhagen University Hospital, Copenhagen, , Denmark
Department of Hematology, Odense University Hospital, Odense, , Denmark
Helsinki University Hospital Comprehensive Cancer Center, Helsinki, , Finland
Meander Medical Center, Amersfoort, , Netherlands
Jeroen Bosch Hospital, Den Bosch, , Netherlands
Haga Hospital, loc. Leyweg, Den Haag, , Netherlands
Slingeland Hospital, Doetinchem, , Netherlands
Albert Schweitzer Hospital, Dordrecht, , Netherlands
Medisch Spectrum Twente, Enschede, , Netherlands
Universitair Medisch Centrum Groningen, Groningen, , Netherlands
Spaarne Ziekenhuis, Hoofddorp, , Netherlands
Erasmus Medical Center, Rotterdam, , Netherlands
Admiraal de Ruyter Hospital, Vlissingen, , Netherlands
Department of Oncology, Oslo University Hospital, Oslo, , Norway
Stavanger University Hospital, Stavanger, , Norway
Department of Oncology, St. Olavs Hospital, Trondheim, , Norway
Department of Oncology, Skåne University Hospital, Lund, , Sweden
Contact Details
Name: Francesco d'Amore, MD DMSci
Affiliation: Dept. of Hematology, Aarhus University Hospital
Role: PRINCIPAL_INVESTIGATOR
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