Spots Global Cancer Trial Database for Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma
Official Title: A Phase Ib Study Evaluating Cobimetinib Plus Atezolizumab in Patients With Advanced BRAF V600 Wild-Type Melanoma Who Have Progressed During or After Treatment With Anti-PD-1 Therapy and Atezolizumab Monotherapy in Patients With Previously Untreated Advanced BRAF V600 Wild-Type Melanoma
Study ID: NCT03178851
Conditions
Study Description
Brief Summary: This study will evaluate the preliminary efficacy, safety, and pharmacokinetics of cobimetinib and atezolizumab in participants with advanced BRAF V600-wild type (WT), metastatic, or unresectable locally advanced melanoma who have progressed on prior anti-PD-1 therapy. In addition, this study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab monotherapy in participants with BRAFV600-WT metastatic or unresectable locally advanced melanoma, who have not been previously treated.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
HonorHealth Research Institute - Bisgrove, Scottsdale, Arizona, United States
University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora, Colorado, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Baylor University Medical Center, Dallas, Texas, United States
Blacktown Hospital, Blacktown, New South Wales, Australia
Melanoma Institute Australia, North Sydney, New South Wales, Australia
Mid North Coast Cancer Institute, Port Macquarie, New South Wales, Australia
Greenslopes Private Hospital; Clinic Pharmacy, Greenslopes, Queensland, Australia
Flinders Medical Centre, Bedford Park, South Australia, Australia
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
Alfred Hospital, Melbourne, Victoria, Australia
University Clinical Centre of the Republic of Srpska, Banja Luka, , Bosnia and Herzegovina
University Clinic Ctr Sarajevo, Sarajevo, , Bosnia and Herzegovina
Instituto de Ensino e Pesquisa Clinica do Ceara, Fortaleza, CE, Brazil
Cenantron - Centro Avancado de Tratamento Oncologico, Belo Horizonte, MG, Brazil
Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro, RJ, Brazil
Hospital Sao Vicente de Paulo, Passo Fundo, RS, Brazil
Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil
Hospital Sao Lucas - PUCRS, Porto Alegre, RS, Brazil
Hospital Amaral Carvalho, Jau, SP, Brazil
Cape Town Oncology Trials, Cape Town, , South Africa
GVI Constantiaberg, Cape Town, , South Africa
Johese Clinical Research, Centurion, , South Africa
Cancercare, George, , South Africa
Wits Clinical Research; Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, , South Africa
Cancercare, Port Elizabeth, , South Africa
Steve Biko Academic Hospital; Oncology, Pretoria, , South Africa
Hospital Clinico Universitario de Santiago, Santiago de Compostela, LA Coruña, Spain
Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Hospital Universitario Virgen Macarena, Seville, Sevilla, Spain
Hospital Universitari Quiron Dexeus, Barcelona, , Spain
Hospital Clinic I Provincial, Barcelona, , Spain
MD Anderson Cancer Center, Madrid, , Spain
Hospital Universitario Ramón y Cajal; Pharmacy, Madrid, , Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Central Municipal Hospital - Uzhgorod State University, Uzhgorod, Chernihiv Governorate, Ukraine
Public Institution: City Multispecialty Clinical Hospital #4 under Dnipropetrovsk Regional Council, Dnipropetrovsk, , Ukraine
National Cancer Institute MOH of Ukraine, Kiev, , Ukraine
Lviv State Oncology Regional Treatment and Diagnostic Centre, Lviv, , Ukraine
Sumy Regional Clinical Onc Ctr, Sumy, , Ukraine
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
