Spots Global Cancer Trial Database for Anesthesia and Cancer Recurrence im Malignant Melanoma
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Trial Identification
Brief Title: Anesthesia and Cancer Recurrence im Malignant Melanoma
Official Title: Long-term Outcome After Radical Lymph Node Dissection of Malignant Melanoma. Comparison Between Regional Versus General Anesthesia With Respect to Impact of Perioperative Immunoediting and Validation of New Potential Predictive Biomarkers
Study ID: NCT01588847
Conditions
Study Description
Brief Summary: Studies in animals and retrospective studies in humans show that regional anesthesia reduces metastatic cancer dissemination. The investigators hypothesize that in patients suffering from malignant melanoma who have to undergo radical inguinal lymph node dissection immune function will be less compromised and long term survival will be superior when spinal anesthesia is compared to general anesthesia.
Detailed Description: Results of basic science indicate that regional anesthesia prevents perioperative immunosuppression and reduces postoperative metastatic cancer dissemination. If this would occur in humans, optimised anesthetic management might improve long-term outcome after cancer surgery.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fachklinik Hornheide, Department of Anesthesiology, Intensive Care and Pain Therapy, Münster, , Germany
Contact Details
Name: Hugo K Van Aken, MD PhD
Affiliation: University Hospital Muenster, Department of Anesthesia, Intensive Care and Pain Therapy
Role: STUDY_CHAIR
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