Spots Global Cancer Trial Database for Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma

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Trial Identification

Brief Title: Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma

Official Title: Surgery and Intracavitary Photodynamic Therapy (PDT) for the Treatment of Malignant Pleural Mesothelioma; The Use of Light Delivery Fibers With Large Diffusers

Study ID: NCT00054002

Conditions

Malignant Mesothelioma

Interventions

adjuvant therapy

conventional surgery

porfimer sodium

Study Description

Brief Summary: RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill cancer cells. Combining photodynamic therapy with surgery may be an effective treatment for malignant mesothelioma. PURPOSE: Phase II trial to study the effectiveness of combining photodynamic therapy with surgery in treating patients who have malignant mesothelioma.

Detailed Description: OBJECTIVES: * Determine the feasibility of adjuvant photodynamic therapy with large diffuser fibers in patients with malignant mesothelioma undergoing surgery. * Compare results of this regimen in these patients to historical controls. * Determine the toxic effects of this regimen in these patients. OUTLINE: This is a pilot study. Patients receive porfimer sodium IV over 5-10 minutes on day 1. Patients undergo pleurectomy or pleuropneumonectomy followed by intracavitary photodynamic therapy on day 3. Patients are followed at 1 month, every 4 months for 2 years, and then every 6 months for 3 years. PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study within 3 years.