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Brief Title: CART Therapy in GUCY2C-positive Digestive Tract Tumors
Official Title: Clinical Study on the Safety and Efficacy of CART Cells in the Treatment of Advanced GUCY2C-positive Digestive Tract Tumors
Study ID: NCT04652219
Brief Summary: Ict-gc is an open, single-center study to evaluate the safety and efficacy of CAR-T-targeted therapy in patients with advanced gastrointestinal tumors.
Detailed Description: The primary objective of phase 1 is to evaluate the safety of CART regimens. The primary objective of phase 2 is to evaluate the efficacy of CART, as measured by objective response rate in subjects with colorectal cancer. Secondary objectives will include assessing the safety and tolerability of CART and additional efficacy endpoints.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
First affiliated hospital, Zhejiang University, Hangzhou, Zhejiang, China
Name: Weijia Fang
Affiliation: First Affiliated Hospital,Zhejiang University
Role: PRINCIPAL_INVESTIGATOR