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Brief Title: A Clinical Trial of ADI-PEG 20TM in Patients With Malignant Pleural Mesothelioma
Official Title: A Randomized Stratified Multicentre Phase II Clinical Trial of Single Agent ADI-PEG 20TM (Pegylated Arginine Deiminase) in Patients With Malignant Pleural Mesothelioma
Study ID: NCT01279967
Brief Summary: To examine whether the arginine depleting drug, ADI-PEG 20, might be effective as a targeted therapy in patients with ASS-negative malignant pleural mesothelioma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The Royal Sussex County Hospital, Brighton, , United Kingdom
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, , United Kingdom
Hull and East Yorkshire Hospitals NHS Trust,The Princess Royal Hospital, Hull, , United Kingdom
Barts and The London NHS, St Bartholomew's Hospital, London, , United Kingdom
Guy's and St Thomas' Foundation Trust, Guy's Hospital, London, , United Kingdom
University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, , United Kingdom
Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, , United Kingdom
Name: Peter Szlosarek
Affiliation: Barts and the London NHS
Role: PRINCIPAL_INVESTIGATOR