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Spots Global Cancer Trial Database for Pharmacogenetics Of Vinorelbine In Malignant Pleural Mesothelioma Patients

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Trial Identification

Brief Title: Pharmacogenetics Of Vinorelbine In Malignant Pleural Mesothelioma Patients

Official Title: Pharmacogenetics of Vinorelbine in Malignant Pleural Mesothelioma Patient

Study ID: NCT01865045

Interventions

Study Description

Brief Summary: This is a multicenter retrospective analysis .The aim of the present study is to investigate the molecular predictors of vinorelbine response in tumor samples of a series of MPM patients and evaluate the possible impact on clinical outcome. Sample size: around 150 patients based on the availability of tumor size

Detailed Description: Vinorelbine has recently become an alternative option for palliation in selected pemetrexed-pretreated patients with malignant pleural mesothelioma (MPM). However, nowadays there are no definitive data about vinorelbine predictors of response in MPM patients. The identification of molecular predictors of effective therapy is important for maximizing therapeutic efficacy and minimizing useless treatment in cancer patients. In oncology a pharmacogenetic approach to customize the chemotherapy treatment according to individual as well as tumour genetic characteristics represents a modern and intriguing challenge. Recent studies have suggested that the expression levels of class III β-tubulin (TUBB3) or BRCA1, are related to a survival benefit from vinorelbine chemotherapy among patients with advanced solid malignancies, especially non-small cell lung cancer. There are no data about the predictive factors to vinorelbine in MPM patients. The identification of molecular predictors of effective therapy may allow in the future the development of better therapies.

Keywords

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Istituto Clinico Humanitas, Rozzano, Milan, Italy

Contact Details

Name: armando santoro, MD

Affiliation: Istituto Clinico Humanitas

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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