Spots Global Cancer Trial Database for Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

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Trial Identification

Brief Title: Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

Official Title: An Open-label, Phase 1/2 Study of Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

Study ID: NCT04765462

Conditions

Malignant Solid Tumours

Interventions

Allogeneic γδ T cells

Study Description

Brief Summary: The study is to determine the safety, feasibility and efficacy of allogeneic γδ T cell therapy in patients with solid tumors.

Detailed Description: This is an open-label, single-center, phase 1/2 study to evaluate the safety, feasibility and efficacy of allogeneic γδ T cell therapy. In phase 1 period, a typical 3+3 dose-escalation design will be used to determine the optimal dose level based on the incidence of dose-limiting toxicity (DLT), which will be recommended as the fixed dose level in the following expansion period and phase 2. The initial infusion dose level will start from 2x10\^6/kg to 5x10\^7/kg in every 2-4 weeks. Combinations with chemotherapy, targeted therapy, radiotherapy, immune checkpoint inhibitors and other therapies are allowed in this study depending on the disease status of the enrolled patients.