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Spots Global Cancer Trial Database for Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

Official Title: An Open-label, Phase 1/2 Study of Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors

Study ID: NCT04765462

Study Description

Brief Summary: The study is to determine the safety, feasibility and efficacy of allogeneic γδ T cell therapy in patients with solid tumors.

Detailed Description: This is an open-label, single-center, phase 1/2 study to evaluate the safety, feasibility and efficacy of allogeneic γδ T cell therapy. In phase 1 period, a typical 3+3 dose-escalation design will be used to determine the optimal dose level based on the incidence of dose-limiting toxicity (DLT), which will be recommended as the fixed dose level in the following expansion period and phase 2. The initial infusion dose level will start from 2x10\^6/kg to 5x10\^7/kg in every 2-4 weeks. Combinations with chemotherapy, targeted therapy, radiotherapy, immune checkpoint inhibitors and other therapies are allowed in this study depending on the disease status of the enrolled patients.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Biotherapeutic Department of Chinsese PLA Gereral Hospital, Beijing, Beijing, China

Contact Details

Name: Weidong Han, M.D

Affiliation: Biotherapeutic Department of Chinese PLA General Hospital

Role: PRINCIPAL_INVESTIGATOR

Name: Yanshan Li

Affiliation: Biotherapeutic Department of Chinese PLA General Hospital

Role: PRINCIPAL_INVESTIGATOR

Name: Kaichao Feng

Affiliation: Biotherapeutic Department of Chinese PLA General Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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