Spots Global Cancer Trial Database for Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury
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Trial Identification
Brief Title: Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury
Official Title: Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy: a Double-blind Randomized Clinical Trial
Study ID: NCT02641938
Conditions
Study Description
Brief Summary: To investigate the renal protective effect of dexmedetomidine in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy
Detailed Description: A cytoreductive surgery and hyperthermic intraperitoneal chemotherapy may lead to the renal hypoperfusion, systemic inflammatory response, and oxidative stress. Dexmedetomidine has been known to protect the kidney against inflammation and oxidative stress in diverse clinical settings. It may also enhance a renal perfusion by inhibition of renal sympathoexcitation. We hypothesized administration of dexmedetomidine might protect the kidney in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy.
Keywords
Eligibility
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
GangnamSH, Seoul, , Korea, Republic of
Contact Details
Name: Ji-Young Kim, MD
Affiliation: Yonsei University Medical College Gangnam Severance Hospital
Role: PRINCIPAL_INVESTIGATOR
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