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Brief Title: Study of Zanubrutinib (BGB-3111) in Participants With Marginal Zone Lymphoma
Official Title: A Phase 2, Open-label Study of Zanubrutinib (BGB-3111) in Patients With Relapsed or Refractory Marginal Zone Lymphoma
Study ID: NCT03846427
Brief Summary: This is a single arm study to evaluate the efficacy, safety and tolerability of zanubrutinib (BGB-3111) in participants with relapsed/refractory marginal zone lymphoma (R/R MZL).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Clinical Research Alliance, Inc., Westbury, New York, United States
The Charlotte-Mecklenburg Hospital Authority, Charlotte, North Carolina, United States
Canberra Hospital, Garran, Australian Capital Territory, Australia
Concord Repatriation General Hospital, Concord, New South Wales, Australia
St George Hospital, Kogarah, New South Wales, Australia
Princess Alexandra Hospital (AUS), Woolloongabba, Queensland, Australia
Flinders Medical Centre, Bedford Park, South Australia, Australia
Box Hill Hospital (AUS), Box Hill, Victoria, Australia
Monash Medical Centre, Clayton, Victoria, Australia
Peninsula Private Hospital, Frankston, Victoria, Australia
Henan Cancer Hospital, Zhengzhou, Henan, China
Institute of Hematology and Hospital of Blood Disease, Tianjin, Tianjin, China
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Peking University Third Hospital, Beijing, , China
Fakultni nemocnice Kralovske Vinohrady, Praha 10, , Czechia
Hopital de la Conception - APHM, Marseille Cedex 05, Bouches-du-Rhône, France
Centre de Lutte Contre Le Cancer - Institut Bergonie, Bordeaux, , France
Hôpital Saint-Louis, Paris, , France
Centre Hospitalier Lyon Sud, Pierre-Bénite, , France
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna, , Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milano, , Italy
A.O.U. Policlinico di Modena, Modena, , Italy
Azienda Ospedaliero - Universitaria Maggiore delle Carità, Novara, , Italy
Azienda Ospedaliera S. Maria Di Terni, Terni, , Italy
Severence Hospital, Seoul, , Korea, Republic of
North Shore Hospital (NZ), Auckland, , New Zealand
Auckland City Hospital, Auckland, , New Zealand
University College London Hospitals, London, Greater London, United Kingdom
Royal Marsden Hospital- London, London, Greater Longon, United Kingdom
The Christie, Manchester, Greater Manchester, United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, Strathclyde, United Kingdom
Name: Study Director
Affiliation: BeiGene
Role: PRINCIPAL_INVESTIGATOR