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Brief Title: Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
Official Title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Study ID: NCT03395197
Brief Summary: This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.
Detailed Description: Part 1 is an open-label, non-randomized, safety and PK run-in study designed to confirm the starting dose of talazoparib in combination with enzalutamide through assessment of target safety events and PK at select sites. Part 2 is a randomized, double-blind, placebo-controlled, multinational study comparing talazoparib plus enzalutamide vs. placebo plus enzalutamide in patients with mCRPC.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Alaska Urological Institute dba Alaska Clinical Research Center, Anchorage, Alaska, United States
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Chandler, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Gilbert, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Mesa, Arizona, United States
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers, Scottsdale, Arizona, United States
Arizona Urology Specialists, Tucson, Arizona, United States
Arizona Urology Specialists, Tucson, Arizona, United States
Beverly Hills Cancer Center, Beverly Hills, California, United States
South County Hematology/Oncology, Chula Vista, California, United States
Sharp Rees-Stealy, Chula Vista, California, United States
Glendale Adventist Medical Center, Glendale, California, United States
Marin Cancer Care, Inc., Greenbrae, California, United States
Cancer Center Oncology Medical Group, La Mesa, California, United States
Loma Linda University Cancer Center - Hematology/Oncology Clinic, Loma Linda, California, United States
Loma Linda University Medical Center, Loma Linda, California, United States
VA Long Beach Healthcare System, Long Beach, California, United States
UCLA Clark Urology Center, Los Angeles, California, United States
University of California, Irvine Medical Center, Orange, California, United States
Stanford Cancer Institute, Palo Alto, California, United States
Desert Hematology Oncology Medical Group, Incorporation, Rancho Mirage, California, United States
Eisenhower Medical Center, Rancho Mirage, California, United States
Medical Oncology Associates-SD, San Diego, California, United States
Sharp Memorial Hospital Investigational Pharmacy, San Diego, California, United States
Sharp Rees-Stealy, San Diego, California, United States
Stanford Health Care, Stanford, California, United States
University of Colorado Denver CTO/CTRC, Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora, Colorado, United States
University of Colorado Hospital- Anschutz Inpatient Pavilion, Aurora, Colorado, United States
University of Colorado Hospital- Anschutz Outpatient Pavilion, Aurora, Colorado, United States
University of Colorado Hospital, Aurora, Colorado, United States
The Urology Center of Colorado, Denver, Colorado, United States
Florida Cancer Specialists, Altamonte Springs, Florida, United States
Florida Cancer Specialists, Brandon, Florida, United States
AdventHealth Medical Group Hematology & Oncology at Celebration, Celebration, Florida, United States
Florida Cancer Specialists, Clearwater, Florida, United States
Florida Cancer Specialists, Daytona Beach, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialists, Gainesville, Florida, United States
AdventHealth Medical Group Hematology & Oncology at Kissimmee, Kissimmee, Florida, United States
Lakeland Regional Health Hollis Cancer Center, Lakeland, Florida, United States
Florida Cancer Specialists, Largo, Florida, United States
Florida Cancer Specialists, Lecanto, Florida, United States
Florida Cancer Specialists, New Port Richey, Florida, United States
Florida Cancer Specialists, Ocala, Florida, United States
Florida Cancer Specialists, Orange City, Florida, United States
AdventHealth Orlando, Orlando, Florida, United States
Investigational Drug Services, Advent Health Orlando, Orlando, Florida, United States
Florida Cancer Specialists, Orlando, Florida, United States
Florida Cancer Specialists, Saint Petersburg, Florida, United States
Florida Cancer Specialists, Spring Hill, Florida, United States
Florida Cancer Specialists, Stuart, Florida, United States
Florida Cancer Specialists, Tampa, Florida, United States
Florida Cancer Specialists, Tavares, Florida, United States
Florida Cancer Specialists, The Villages, Florida, United States
Florida Cancer Specialists, Vero Beach, Florida, United States
Florida Cancer Specialists, Wellington, Florida, United States
Florida Cancer Specialists, West Palm Beach, Florida, United States
Florida Cancer Specialists, Winter Park, Florida, United States
Piedmont Cancer Institute, Atlanta, Georgia, United States
Piedmont Cancer Institute, Fayetteville, Georgia, United States
Piedmont Cancer Institute, Newnan, Georgia, United States
Southeastern Regional Medical Center, Newnan, Georgia, United States
Cook County Health (CCH), Chicago, Illinois, United States
John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy, Chicago, Illinois, United States
AMITA Health Adventist Medical Center Hinsdale, Hinsdale, Illinois, United States
AMITA Health Cancer Institute, Hinsdale, Illinois, United States
Midwestern Regional Medical Center, Zion, Illinois, United States
Clark Memorial Hospital Radiology, Jeffersonville, Indiana, United States
First Urology, PSC, Jeffersonville, Indiana, United States
University of Iowa Hospital and Clinics, Iowa City, Iowa, United States
The University of Kansas Clinical Research Center, Fairway, Kansas, United States
The University of Kansas Cancer Center, Westwood, Kansas, United States
Ochsner Clinic Foundation, New Orleans, Louisiana, United States
VA Saint Louis Healthcare System, Saint Louis, Missouri, United States
GU Research Network/Urology Cancer Center, Omaha, Nebraska, United States
Clara Maass Medical Center, Belleville, New Jersey, United States
New Jersey Cancer Care and Blood Disorders, Belleville, New Jersey, United States
University Radiology, Nutley, New Jersey, United States
New Jersey Urology, LLC, Voorhees, New Jersey, United States
Urology Group of New Mexico, Albuquerque, New Mexico, United States
San Juan Oncology Associates, Farmington, New Mexico, United States
Montefiore Medical Center - Montefiore Medical Park, Bronx, New York, United States
Premier Medical Group of the Hudson Valley PC, Poughkeepsie, New York, United States
Associated Medical Professionals of New York, PLLC, Syracuse, New York, United States
TriState urologic Services PSC Inc., dba The Urology Group, Cincinnati, Ohio, United States
Clinical Research Solutions, Middleburg Heights, Ohio, United States
Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
Kaiser Sunnyside Medical Center, Clackamas, Oregon, United States
Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States
Kaiser Westside Medical Center, Hillsboro, Oregon, United States
Providence Cancer Institute Newberg Clinic, Newberg, Oregon, United States
Providence Newberg Medical Center, Newberg, Oregon, United States
Providence Cancer Institute Willamette Falls, Oregon City, Oregon, United States
Providence Cancer Institute Franz Clinic, Portland, Oregon, United States
Providence Portland Medical Center, Portland, Oregon, United States
Providence Oncology and Hematology Care Clinic - Westside, Portland, Oregon, United States
Providence St. Vincent Medical Center, Portland, Oregon, United States
Kaiser Permanente Northwest, Portland, Oregon, United States
UPMC Hillman Cancer Center - Altoona, Altoona, Pennsylvania, United States
UPMC Hillman Cancer Center - Upper St. Clair, Bethel Park, Pennsylvania, United States
UPMC Hillman Cancer Center - Arnold Palmer - Mt View, Greensburg, Pennsylvania, United States
Keystone Urology Specialists, Lancaster, Pennsylvania, United States
UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant (HOA), Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant (OHA), Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Northwest, Seneca, Pennsylvania, United States
UPMC Hillman Cancer Center - Uniontown, Uniontown, Pennsylvania, United States
UPMC Hillman Cancer Center - Washington, Washington, Pennsylvania, United States
Carolina Urologic Research Center, Myrtle Beach, South Carolina, United States
Sarah Cannon Research Institute, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC, Chattanooga, Tennessee, United States
Tennesse Oncology, PLLC, Cleveland, Tennessee, United States
Urology Associates P.C., Nashville, Tennessee, United States
The Vanderbilt Clinic, Nashville, Tennessee, United States
Vanderbuilt University Medical Center, Department of Urology, Nashville, Tennessee, United States
Urology Austin PLLC, Austin, Texas, United States
Rio Grande Urology, P.A., El Paso, Texas, United States
Houston Metro Urology, Houston, Texas, United States
Urology Austin, PLLC, Round Rock, Texas, United States
Baylor Scott & White Medical Center - Temple, Temple, Texas, United States
Farmington Health Center -University of Utah, Farmington, Utah, United States
Huntsman Cancer Hospital, Salt Lake City, Utah, United States
University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, United States
Redwood Health Center-University of Utah, Salt Lake City, Utah, United States
South Jordan Health Center -University of Utah, South Jordan, Utah, United States
Inova Schar Cancer Institute Infusion Pharmacy, Fairfax, Virginia, United States
Inova Schar Cancer Institute, Fairfax, Virginia, United States
Swedish Cancer Institute, Seattle, Washington, United States
Swedish Medical Center, Seattle, Washington, United States
University of Wisconsin Clinical Science Center, Madison, Wisconsin, United States
University of Wisconsin Hospital & Clinics, Madison, Wisconsin, United States
Centro de Investigacion Pergamino SA - Clinica Pergamino SA, Pergamino, Buenos Aires, Argentina
Instituto de Oncologia de Rosario, Rosario, Santa FE, Argentina
Hospital Británico de Buenos Aires, Caba, , Argentina
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" Cemic, Caba, , Argentina
Clinica Universitaria Reina Fabiola, Cordoba, , Argentina
Hospital Privado Centro Medico de Cordoba, Cordoba, , Argentina
Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia
St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
Port Macquarie Base Hospital, Port Macquarie, New South Wales, Australia
ICON Cancer Centre Wesley, Auchenflower, Queensland, Australia
River City Pharmacy, Auchenflower, Queensland, Australia
Princess Alexandra Hospital, Brisbane, Queensland, Australia
ICON Cancer Centre Chermside, Chermside, Queensland, Australia
ICON Cancer Centre South Brisbane, South Brisbane, Queensland, Australia
Integrated Clinical Oncology Network Pty Ltd (ICON), South Brisbane, Queensland, Australia
ICON Cancer Centre Southport, Southport, Queensland, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Peter MacCallum Cancer Centre, North Melbourne, Victoria, Australia
AZ Klina, Brasschaat, , Belgium
A.Z. Sint-Lucas, Gent, , Belgium
UZ Gent, Gent, , Belgium
AZ Groeninge, Kortrijk, , Belgium
Clinique Saint-Pierre Ottignies, Ottignies, , Belgium
CHU UCL Namur site Godinne, Yvoir, , Belgium
Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA, Rio de Janeiro, RJ, Brazil
Instituto Nacional de Câncer José de Alencar Gomes da Silva - INCA, Rio de Janeiro, RJ, Brazil
Hospital Universitario Pedro Ernesto-Centro de Pesquisas (CEPUSA), Rio de Janeiro, RJ, Brazil
Hospital CopaDor, Rio de Janeiro, RJ, Brazil
Hospital Gloria D'Or, Rio de Janeiro, RJ, Brazil
Oncologia D'Or, Rio de Janeiro, RJ, Brazil
Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
Oncologia D'Or, Rio de Janeiro, RJ, Brazil
Associacao Hospital de Caridade de Ijui, Ijui, RS, Brazil
Sociedade Beneficencia e Caridade de Lajeado - Hospital Bruno Born, Lajeado, RS, Brazil
Centro de Pesquisa Clinica em Oncologia - Hospital Sao Lucas da Pontificia Universidade Catolica, Porto Alegre, RS, Brazil
Centro Gaucho Integrado - Hospital Mae de Deus, Porto Alegre, RS, Brazil
MedPlex Eixo Norte, Porto Alegre, RS, Brazil
Hospital Nossa Senhora da Conceicao - Grupo Hospitalar Conceicao, Porto Alegre, RS, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos, SP, Brazil
Faculdade de Medicina do ABC - Centro de Estudos e Pesquisa de Hematologia e Oncologia (CEPHO), Santo Andre, SP, Brazil
Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Oncologia (CEPHO), Santo Andre, SP, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, Brazil
Instituto do Cancer do Estado de Sao Paulo-ICESP-Nucleo de Pesquisa, Sao Paulo, SP, Brazil
Hospital Alemão Oswaldo Cruz, Sao Paulo, SP, Brazil
Tom Baker Cancer Centre - Alberta Health Services, Calgary, Alberta, Canada
The Ottawa Hospital Cancer Center, Ottawa, Ontario, Canada
Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean, Chicoutimi, Quebec, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada
Jewish General Hospital, Montreal, Quebec, Canada
Centre integre universitaire de sante et de services sociaux de l'Estrie, Sherbrooke, Quebec, Canada
Sociedad Prosalud Montes y Orlandi Ltda. Fantasy name (Orlandi Oncologia), Santiago, Metropolitana, Chile
Centro de Investigacion Clinica del Sur, Temuco, Region DE LA Araucania, Chile
Sociedad de Investigaciones Medicas Ltda (SIM), Temuco, Region DE LA Araucania, Chile
Sociedad de Investigaciones Medicas Ltda (SIM), Temuco, Region DE LA Araucania, Chile
Centro de Investigaciones Clinicas Vina del Mar, Vina del Mar, Valparaiso, Chile
Centro de Investigaciones Clinicas Vina del Mar, Vina del Mar, Valparaiso, Chile
James Lind Centro de lnvestigacion del Cancer, Araucania, , Chile
The First affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Peking University First Hospital / Urology Department, Beijing, Beijing, China
Beijing Cancer Hospital, Beijing, Beijing, China
Peking University Third Hospital, Beijing, Beijing, China
Beijing Hospital, Beijing, Beijing, China
The First Affiliated Hospital Of Fujian Medical University, Fuzhou, Fujian, China
First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
Union Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, Hubei, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China
Nanjing First Hospital, Nanjing, Jiangsu, China
Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China
Nantong Tumor Hospital, Nantong, Jiangsu, China
Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu, China
Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu, China
Wuxi People's Hospital, Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Jilin Cancer Hospital, Changchun, Jilin, China
Jilin Province Tumor Hospital, Changchun, Jilin, China
Zhongshan Hospital Fudan University, Shanghai, Shanghai, China
Shanghai General Hospital, Shanghai, Shanghai, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
West China Hospital of Sichuan University, Chengdu, Sichuan, China
Yunnan Cancer Hospital, Kunming, Yunnan, China
Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Ningbo First Hospital, Ningbo, Zhejiang, China
The first affiliated hospital of Ningbo University, Ningbo, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
The First Affiliated Hosptial of Wenzhou Medical University, Wenzhou, Zhejiang, China
Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, , China
Chongqing University Cancer Hospital, Chongqing, , China
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, , China
Fudan University Cancer Hospital, Deptartment of Urology, Shanghai, , China
Shanghai Tenth People's Hospital, Shanghai, , China
The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, , China
The Second Hospital of Tianjin Medical University, Tianjin, , China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, , China
Fakultní nemocnice Hradec Králové, Hradec Kralove, , Czechia
Fakultni nemocnice Ostrava, Ostrava-Poruba, , Czechia
Multiscan s.r.o., Pardubice, , Czechia
Fakultní nemocnice Královské Vinohrady, Praha 10, , Czechia
HUS Helsinki University Hospital, Helsinki, , Finland
Docrates Cancer Center, Helsinki, , Finland
OYS apteekki, Kempele, , Finland
Kuopio University Hospital, Kuopio, , Finland
Kuopio University Hospital, Kuopio, , Finland
Oulun yliopistollinen sairaala, Oulu, , Finland
Tampere University Hospital, Tampere, , Finland
Turku University Hospital, Turku, , Finland
Centre d'Oncologie du Pays-Basque, Bayonne, , France
Clinique Ramsay Belharra, Bayonne, , France
Hopital Saint Andre - CHU de Bordeaux, Bordeaux, , France
CHD Vendée, LA ROCHE SUR YON cedex 9, , France
Centre de cancerologie de la Sarthe, Le Mans, , France
Clinique Victor Hugo-Centre Jean Bernard, Le Mans, , France
Clinique Victor Hugo, Le Mans, , France
Centre Leon Berard, Lyon Cedex 08, , France
Centre Léon Bérard, Lyon CEDEX 08, , France
CHU Montpellier-Hopital Saint Eloi, Montpellier cedex 5, , France
Hopital Europeen Georges Pompidou, Paris Cedex 15, , France
Hopital Saint-Louis, Paris, , France
Clinique Sainte Anne, Strasbourg, , France
Hopitaux Universitaires de Strasbourg - ICANS, Strasbourg, , France
Hopital Foch, Suresnes Cedex, , France
Hopital Foch, Suresnes, , France
Institut Gustave Roussy, VILLEJUIF cedex, , France
Universitaetsklinikum Duesseldorf, Duesseldorf, , Germany
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, , Germany
Universitaetsklinik Heidelberg, Heidelberg, , Germany
Diagnostikzentrum, Kirchheim, , Germany
Universitaetsklinikum Muenster, Muenster, , Germany
Studienpraxis Urologie, Nuertingen, , Germany
Semmelweis Egyetem Urologiai Klinika, Budapest, , Hungary
Országos Onkológiai Intézet, Budapest, , Hungary
Uzsoki Utcai Korhaz, Budapest, , Hungary
Uzsoki Utcai Kórház, Budapest, , Hungary
Debreceni Egyetem Klinikai Kozpont, Debrecen, , Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intezet, Pecs, , Hungary
Rambam Health Care Campus, Haifa, , Israel
Shaare Zedek Medical Center, Jerusalem, , Israel
Tel Aviv Sourasky Medical Center, Tel Aviv, , Israel
Azienda Ospedaliero-Universitaria Policlinico Sant' Orsola Malpighi, Bologna, BO, Italy
ASST di Cremona, Cremona, CR, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy
Azienda Ospedaliera S. Maria, Terni, TN, Italy
Ospedale Santa Chiara, Trento, TN, Italy
AOU San Luigi Gonzaga, Orbassano, TO, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - Napoli, Napoli, , Italy
Nagoya University Hospital, Nagoya, Aichi, Japan
Hirosaki University School of Medicine & Hospital, Hirosaki, Aomori, Japan
National Cancer Center Hospital East, Kashiwa, Chiba, Japan
National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan
Hokkaido University Hospital, Sapporo, Hokkaido, Japan
Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan
Osaka International Cancer Institute, Osaka-shi, Osaka, Japan
Kindai University Hospital, Osakasayama, Osaka, Japan
Osaka University Hospital, Suita, Osaka, Japan
Hamamatsu University School of Medicine, University Hospital, Hamamatsu, Shizuoka, Japan
National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan
Keio University Hospital, Shinjuku-ku, Tokyo, Japan
Chiba Cancer Center, Chiba, , Japan
National Hospital Organization Kyushu Cancer Center, Fukuoka, , Japan
Kagoshima University Hospital, Kagoshima, , Japan
National Hospital Organization Kumamoto Medical Center, Kumamoto, , Japan
Tokushima University Hospital, Tokushima, , Japan
Yamagata Prefectural Central Hospital, Yamagata, , Japan
Yamagata University Hospital, Yamagata, , Japan
Clinical Trial Pharmacy, National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of
National Cancer Center, Goyang-si, Gyeonggi-do, Korea, Republic of
Pusan National University Hospital, Busan, , Korea, Republic of
Kyungpook National University Chilgok Hospital, Daegu, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Cancer Center Clinical Trial, Asan Medical Center, Seoul, , Korea, Republic of
Clinical Trials Center Pharmacy, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Clinical Trial Pharmacy, The Catholic University of Korea, Seoul, , Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, , Korea, Republic of
Tauranga Urology Research Limited, Tauranga, BAY OF Plenty, New Zealand
Canterbury District Health Board, Christchurch, Canterbury, New Zealand
Waikato Hospital, Hamilton, Waikato, New Zealand
Auckland City Hospital, Auckland, , New Zealand
Sykehusapoteket Ostfold, Kalnes, Gralum, , Norway
Ostfold County Hospital, Kalnes, Gralum, , Norway
Akershus University Hospital, Lorenskog, , Norway
Oslo University Hospital -Ullevål & Radiumhospitalet, Oslo, , Norway
St. Olavs Hospital, Trondheim University Hospital, Trondheim, , Norway
Clinica Monte Carmelo S.C.R.LTDA., Arequipa, , Peru
Hospital Militar Central "Coronel Luis Arias Schreiber", Lima, , Peru
Clinica Internacional Sede San Borja, Lima, , Peru
Clinica Oncosalud, Lima, , Peru
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. ks. B. Markiewicza, Brzozow, , Poland
Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii i Radioterapii, Gdynia, , Poland
Przychodnia Lekarska "Komed" Roman Karaszewski, Konin, , Poland
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Otwock, , Poland
City Clinic Sp. z o.o., Warszawa, , Poland
NZOZ Szpital Mazovia; Oddzial urologiczny, Warszawa, , Poland
Centro Clínico Académico - Braga, Associação (2CABraga), Braga, , Portugal
Instituto Português Oncologia de Coimbra Francisco Gentil - E.P.E, Coimbra, , Portugal
Fundação Champalimaud, Lisboa, , Portugal
Hospital da Luz Lisboa, Lisboa, , Portugal
Centro Hospitalar do Porto - Hospital de Santo Antonio, Porto, , Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, Porto, , Portugal
Cancercare Langenhoven Drive Oncology Centre, Port Elizabeth, Eastern CAPE, South Africa
Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Clinical Trial Site, Johannesburg, Gauteng, South Africa
Wits Clinical Research, Johannesburg, Gauteng, South Africa
The Medical Oncology Centre of Rosebank, Johannesburg, Gauteng, South Africa
Wits Clinical Research, Parktown, Gauteng, South Africa
Cancercare Rondebosch Oncology, Cape Town, Western CAPE, South Africa
Outeniqua Cancercare Oncology Unit, George, Western CAPE, South Africa
Cape Town Oncology Trials, Kraaifontein, Cape Town, Western CAPE, South Africa
Wits Clinical Research, Johannesburg, , South Africa
Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
Hospital General Universitario de Elche, Elche, Alicante, Spain
Institut Catala d'Oncologia - ICO L'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain
Corporacio Sanitaria i Universitaria Parc Tauli, Sabadell, Barcelona, Spain
Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital Clinic de Barcelona, Barcelona, , Spain
Hospital Universitario La Princesa, Madrid, , Spain
Hospital General Universitario Gregorio Maranon, Madrid, , Spain
MD Anderson Cancer Center, Madrid, , Spain
Hospital Universitario 12 De Octubre, Madrid, , Spain
Klinisk Provningsenhet (KPE) Onkologi, Goteborg, , Sweden
Patientomrade Backencancer, Tema Cancer, Stockholm, , Sweden
Cancercentrum, Umeå, , Sweden
University Hospitals Plymouth NHS Trust, Plymouth, Devon, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral, United Kingdom
Royal Cornwall Hospitals NHS Trust, Cornwall, , United Kingdom
NHS Greater Glasgow and Clyde, Glasgow, , United Kingdom
The Clatterbridge Cancer Centre - Liverpool, Liverpool, , United Kingdom
Imperial College Healthcare NHS Trust, London, , United Kingdom
Imperial College Healthcare NHS Trust, London, , United Kingdom
Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, , United Kingdom
Oxford University Hospitals NHS Trust, Oxford, , United Kingdom
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