Spots Global Cancer Trial Database for Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging

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Trial Identification

Brief Title: Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging

Official Title: Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging

Study ID: NCT03214341

Conditions

Mediastinal Tumor

Interventions

MRI diffusion

Study Description

Brief Summary: Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis

Detailed Description: Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy is essential for treatment planning as well as for prognosis . MRI presents valuable diagnostic information in assessing the mediastinum. In addition, special applications have been developed over recent years diffusion-weighted magnetic resonance imaging is one such technique The advent of echo-planar imaging technique has rendered diffusion weighted imaging of the abdomen and thoracic cavity possible . Quantitative assessment of the mediastinal mass is possible by calculation of apparent diffusion co-efficient value ,which is related to the proportion of extracellular and intracellular component. The apparent diffusion co-efficient is inversely correlated with tissue cellularity. It is lower in viable tumor tissue with densely packed diffusion-hindering obstacles than in tissue with less densely packed obstacles such as tumor necrosis and benign tissue .